Combined associations of 25-hydroxivitamin D and parathyroid hormone with diabetes risk and associated comorbidities among U.S. white and black women.
Combined associations of 25-hydroxivitamin D and parathyroid hormone with diabetes risk and associated comorbidities among U.S. white and black women.
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DOI：
10.1038/s41387-021-00171-2
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发表时间：
2021-09-16
影响因子：
6.1
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Xia J;Tu W;Manson JE;Nan H;Shadyab AH;Bea JW;Gower EW;Qi L;Cheng TD;Song Y
有证据表明，黑人和白人在维生素D状态和心脏代谢健康方面存在差异。本研究旨在进一步评估25-羟基维生素D [25（OH）D]和甲状旁腺激素（PTH）与白色和黑人女性糖尿病和相关心脏代谢合并症风险的联合相关性。我们对妇女健康倡议观察性研究中基线时无心血管疾病或透析的1850名黑人和3000名白色绝经后妇女的数据进行了横断面和前瞻性分析。采用加权考克斯比例风险分析和加权逻辑回归模型研究25（OH）D和PTH与糖尿病发病率和其他糖尿病相关心脏代谢合并症（包括CKD、高血压或肥胖）患病率的联合相关性。我们确定了3322例肥胖（n = 1629），高血压（n = 2759），或CKD（n = 318）在基线和453例糖尿病事件在11年的随访。在横断面上，仅在白色女性中，25（OH）D较低和PTH较高与高血压患病率较高独立相关[比值比（OR）= 0.79; 95%置信区间（CI）：0.72-0.87和OR = 1.55; 95% CI：1.39-1.73]。当按糖尿病状态分层时，与25（OH）D ≥50 nmol/L和PTH ≤6.89 pmol/L的女性相比，（65 pg/mL），未患糖尿病且维生素D缺乏的女性（<50 nmol/L）和PTH过量（>6.89 pmol/L）的CKD、高血压或肥胖患病率较高（OR = 4.23，95%CI：2.90-6.18）高于糖尿病组（OR = 1.89，95%CI：0.96-3.71）。在白色女性中，低25（OH）D的脯氨酸与较低的糖尿病发病率相关[风险比（HR）= 0.73; 95% CI：0.62-0.86]。总之，与25（OH）D ≥50 nmol/L和PTH ≤6.89 pmol/L的组相比，25（OH）D缺乏（<50 nmol/L）的白色女性患糖尿病的风险升高，无论PTH水平如何。仅在白色女性中，低25（OH）D和高PTH与糖尿病风险增加共同相关。在无糖尿病的女性中，它们与CKD、高血压和肥胖的高患病率的联合关联更为明显。
There is evidence of black–white differences in vitamin D status and cardiometabolic health. This study aimed to further evaluate the joint associations of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) with risks of diabetes and related cardiometabolic comorbidities among white and black women. We cross-sectionally and prospectively analyzed data from 1850 black and 3000 white postmenopausal women without cardiovascular disease or dialysis at baseline from the Women’s Health Initiative—Observational Study. Weighted Cox proportional hazards analyses and weighted logistic regression models were used to examine the joint associations of 25(OH)D and PTH with incident diabetes and prevalence of other diabetes-related cardiometabolic comorbidities (including CKD, hypertension, or obesity). We identified 3322 cases of obesity (n = 1629), hypertension (n = 2759), or CKD (n = 318) at baseline and 453 incident cases of diabetes during 11 years of follow-up. Cross-sectionally, lower 25(OH)D and higher PTH were independently associated with higher prevalence of hypertension [odds ratio (OR) = 0.79; 95% confidence interval (CI): 0.72–0.87 and OR = 1.55; 95% CI: 1.39–1.73] among white women only. When stratified by diabetes status, compared to women with 25(OH)D ≥50 nmol/L and PTH ≤6.89 pmol/L (65 pg/mL), women who did not have diabetes with vitamin D deficiency (<50 nmol/L) and PTH excess (>6.89 pmol/L) had higher prevalence of CKD, hypertension, or obesity (OR = 4.23; 95% CI: 2.90–6.18) than women who had diabetes (OR = 1.89; 95% CI: 0.96–3.71). Prospectively, lower 25(OH)D was associated with lower diabetes incidence [hazard ratio (HR) = 0.73; 95% CI: 0.62–0.86] in white women. Jointly, compared to the group with 25(OH)D ≥50 nmol/L and PTH ≤6.89 pmol/L, white women with 25(OH)D deficiency (<50 nmol/L) had elevated risk for diabetes, regardless of PTH levels. Low 25(OH)D and high PTH were jointly associated with increased risk of diabetes among white women only. Their joint associations with high prevalence of CKD, hypertension, and obesity were more pronounced among women without diabetes.
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影响因子：
2.4
作者：
Karras, Spyridon N.;Anagnostis, Panagiotis;Kotsa, Kalliopi
通讯作者：
Kotsa, Kalliopi
影响因子：
3.7
作者：
Park, Sue K.;Garland, Cedric F.;Barrett-Connor, Elizabeth
通讯作者：
Barrett-Connor, Elizabeth
影响因子：
13.6
作者：
Schoettker, Ben;Herder, Christian;Brenner, Hermann
通讯作者：
Brenner, Hermann
DOI：
10.1152/ajprenal.00406.2006
发表时间：
2007-04-01
影响因子：
4.2
作者：
Rashid, Gloria;Bernheim, Jacques;Benchetrit, Sydney
通讯作者：
Benchetrit, Sydney
影响因子：
15.9
作者：
Li, YC;Kong, J;Cao, LP
通讯作者：
Cao, LP