The Epigenetic Mechanisms Involved in Chronic Pain in Rodents: A Mini- Review.
The Epigenetic Mechanisms Involved in Chronic Pain in Rodents: A Mini- Review.
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DOI：
10.2174/1570159x19666210924104757
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发表时间：
2022
影响因子：
5.3
通讯作者：
Xin, Wen-Jun
中科院分区：
文献类型：
--
作者：
Xu, Ting;Liu, Cui-Cui;Xin, Wen-Jun
关键词：
慢性疼痛是一种常见的令人痛苦的神经系统疾病，全球约有30%的人口患有慢性疼痛。除了非常普遍之外，慢性疼痛还会造成沉重的经济和社会负担。虽然在过去的几十年里，在剖析慢性疼痛的潜在机制方面取得了实质性的进展，但这种神经系统疾病的发病率和治疗在临床实践中尚未得到适当的管理。虽然神经损伤、化疗或炎症诱导的背根神经节和脊髓基因表达的功能调控被广泛报道参与慢性疼痛的致病过程，但这些转录谱改变的具体机制仍不清楚。近年来的研究表明，表观遗传机制，包括DNA/RNA甲基化、组蛋白修饰和环状RNA调控，参与了慢性疼痛的发生和发展。本文综述了表观遗传机制在慢性疼痛中的作用，总结了该领域的最新临床和临床前研究进展，并提出了进一步研究慢性疼痛发病机制的潜在方向。
Chronic pain is a common distressing neurological disorder and about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes a heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene expression in the dorsal root ganglion and spinal cord are extensively reported to be involved in the pathogenic process of chronic pain, the specific mechanism of these altered transcriptional profile still remains unclear. Recent studies have shown that epigenetic mechanisms, including DNA/RNA methylation, histone modification and circular RNAs regulation, are involved in the occurrence and development of chronic pain. In this review, we provide a description of research on the role of epigenetic mechanism in chronic pain, summarize the latest clinical and preclinical advance in this field, and propose the potential directions for further research to elucidate the molecular mechanism underlying the pathogenesis of chronic pain.
乙酰化组蛋白3在大鼠脊髓中的表达及吗啡对大鼠炎性痛的影响
影响因子：
6.1
作者：
Li H;Li C;Dai R;Shi X;Xu J;Zhang J;Zhou X;Li Z;Luo X
通讯作者：
Luo X