MicroRNAs and diabetic complications.
MicroRNAs and diabetic complications.
复制标题
DOI：
10.1007/s12265-012-9368-5
复制
发表时间：
2012-08
影响因子：
3.4
通讯作者：
Kato, Mitsuo
中科院分区：
文献类型：
--
作者：
Natarajan, Rama;Putta, Sumanth;Kato, Mitsuo
1型和2型糖尿病都可导致使人衰弱的微血管并发症，如视网膜病、肾病和神经病，以及大血管并发症，如心血管疾病，包括动脉粥样硬化和高血压。糖尿病并发症可归因于多种促成因素，例如高血糖症、高脂血症、晚期糖基化终产物、生长因子和炎症细胞因子/趋化因子。然而，目前的治疗方法并不完全有效，因此迫切需要更好地了解糖尿病并发症的分子机制，以确定新的治疗靶点。microRNA（miRNAs）是一类通过转录后机制抑制靶基因表达的短链非编码RNA。新的证据表明，它们具有不同的细胞和生物学功能，并在多种疾病中发挥关键作用。本文就miRNAs在糖尿病并发症中的作用进行综述，并探讨其作为糖尿病并发症诊断和治疗新靶点的可能性。
Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing factors such as hyperglycemia, hyperlipidemia, advanced glycation end products, growth factors and inflammatory cytokines/chemokines. However, current therapies are not fully efficacious and hence there is an imperative need for a better understanding of the molecular mechanisms underlying diabetic complications in order to identify newer therapeutic targets. microRNAs (miRNAs) are short non-coding RNAs that repress target gene expression via post-transcriptional mechanisms. Emerging evidence shows that they have diverse cellular and biological functions and play key roles in several diseases. In this review, we explore the role of miRNAs in the pathology of diabetic complications and also discuss the potential use of miRNAs as novel diagnostic and therapeutic targets for diabetic complications.
登录
查看更多内容
影响因子：
7.7
作者：
Fernandez-Valverde SL;Taft RJ;Mattick JS
通讯作者：
Mattick JS
影响因子：
4.4
作者：
Bruno AE;Li L;Kalabus JL;Pan Y;Yu A;Hu Z
通讯作者：
Hu Z
影响因子：
7.7
作者：
Feng B;Chen S;McArthur K;Wu Y;Sen S;Ding Q;Feldman RD;Chakrabarti S
通讯作者：
Chakrabarti S
影响因子：
7.3
作者：
Farazi, Thalia A.;Spitzer, Jessica I.;Morozov, Pavel;Tuschl, Thomas
通讯作者：
Tuschl, Thomas
影响因子：
37.8
作者：
Caporali, Andrea;Meloni, Marco;Emanueli, Costanza
通讯作者：
Emanueli, Costanza