Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.
Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.
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DOI：
10.1136/sti.2010.045369
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发表时间：
2011-03
影响因子：
3.6
通讯作者：
McClelland RS
中科院分区：
文献类型：
--
作者：
Graham SM;Masese L;Gitau R;Richardson BA;Mandaliya K;Peshu N;Jaoko W;Ndinya-Achola J;Overbaugh J;McClelland RS
Genital ulcer disease (GUD) is associated with increased HIV-1 RNA shedding in antiretroviral therapy (ART)-naïve women. The effect of GUD on HIV-1 shedding among ART-treated women is not known. Our objective was to test the hypothesis that genital ulcerations increase genital HIV-1 RNA shedding in women receiving ART. Eligible women initiated ART and attended monthly visits with inspection for genital lesions and collection of genital swabs. GUD cases diagnosed after ≥2 months on ART were included for analysis and served as their own controls. HIV-1 RNA was quantitated in specimens collected before, during, and after GUD for all cases. The lower limit of quantitation was 100 HIV-1 RNA copies/swab. Using the pre-GUD visit as the reference, we compared detection of genital HIV-1 RNA before versus during and after GUD episodes. Thirty-six women had GUD episodes after ART initiation. HIV-1 RNA was detected before, during, and after GUD in cervical secretions from 4 (11%), 1 (3%), and 6 (17%) women respectively, and in vaginal secretions from 3 (8%), 4 (11%) and 4 (11%) women respectively. After adjustment for time on ART, there was no difference in detection of cervical HIV-1 RNA before versus during GUD (aOR 0.22, 95% CI 0.04–1.23). Likewise, GUD did not increase HIV-1 detection in vaginal secretions (adjusted odds ratio [aOR] 1.32, 95% CI 0.29–5.92). GUD did not significantly increase cervical or vaginal HIV-1 shedding. Our results suggest that ART maintains its effectiveness for genital HIV-1 suppression despite GUD episodes.
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DOI：
10.1097/00126334-200408150-00014
发表时间：
2004-08-15
影响因子：
3.6
作者：
Oyugi, JH;Byakika-Tusiime, J;Bangsberg, DR
通讯作者：
Bangsberg, DR
DOI：
10.1097/qai.0b013e3181b065cf
发表时间：
2009-12
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Graham SM;Masese L;Gitau R;Mwakangalu D;Jaoko W;Ndinya-Achola J;Mandaliya K;Peshu N;Baeten JM;McClelland RS
通讯作者：
McClelland RS
影响因子：
3.6
作者：
Mayaud, P.;Nagot, N.;Van de Perre, P
通讯作者：
Van de Perre, P
影响因子：
3.6
作者：
Pickering, JM;Whitworth, JAG;Mayaud, P
通讯作者：
Mayaud, P
影响因子：
6.4
作者：
Mostad, SB;Kreiss, JK;Corey, L
通讯作者：
Corey, L