The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier.
The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier.
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DOI：
10.4103/1673-5374.369102
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发表时间：
2023-10
影响因子：
6.1
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Wei SS;Chen L;Yang FY;Wang SQ;Wang P
再髓鞘化失败是多发性硬化症的主要特征之一，并且可能与疾病进展相关。先前的研究表明，细胞外基质与髓鞘再生失败有关，因为基质的重塑在慢性和进行性多发性硬化症中都经常失败。纤维连接蛋白聚集体组装并持续存在于慢性多发性硬化症中，从而抑制髓鞘再生。虽然在多发性硬化的机制和治疗方面取得了许多进展，但药物仍然很难到达病理脑组织;这是由于脑结构和功能的复杂性，特别是血脑屏障的存在。因此，在此，我们回顾了纤维连接蛋白聚集体对多发性硬化症的影响，以及不同形式的药物递送穿过血脑屏障治疗这种疾病的疗效。
Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression. Previous research has shown that the extracellular matrix is associated with remyelination failure because remodeling of the matrix often fails in both chronic and progressive multiple sclerosis. Fibronectin aggregates are assembled and persistently exist in chronic multiple sclerosis, thus inhibiting remyelination. Although many advances have been made in the mechanisms and treatment of multiple sclerosis, it remains very difficult for drugs to reach pathological brain tissues; this is due to the complexity of brain structure and function, especially the existence of the blood-brain barrier. Therefore, herein, we review the effects of fibronectin aggregates on multiple sclerosis and the efficacy of different forms of drug delivery across the blood-brain barrier in the treatment of this disease.
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DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
6.1
作者：
Cherchi F;Pugliese AM;Coppi E
通讯作者：
Coppi E
影响因子：
0.9
作者：
Dragomir M;Chen B;Calin GA
通讯作者：
Calin GA
影响因子：
25
作者：
Dombrowski Y;O'Hagan T;Dittmer M;Penalva R;Mayoral SR;Bankhead P;Fleville S;Eleftheriadis G;Zhao C;Naughton M;Hassan R;Moffat J;Falconer J;Boyd A;Hamilton P;Allen IV;Kissenpfennig A;Moynagh PN;Evergren E;Perbal B;Williams AC;Ingram RJ;Chan JR;Franklin RJM;Fitzgerald DC
通讯作者：
Fitzgerald DC