HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer.
HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer.
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HURP表达辅助风险评分确定了早期肝癌中可区分的亚组的预后。
DOI：
10.1371/journal.pone.0026323
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Yeh CT
中科院分区：
文献类型：
--
作者：
Chang ML;Lin SM;Yeh CT
肝癌上调蛋白(HURP)是染色质依赖的纺锤体组装途径的组成部分。我们研究了HURP在人肝细胞癌(HCC)中的预后预测价值。应用免疫细胞化学方法检测97例巴塞罗那临床A期肝癌患者细针抽吸肝癌细胞中HURP的表达，并对这些患者行肝部分切除术(n = 18例)或射频消融术(n = 79例)，并随访2~35个月。将临床病理参数提交生存分析。吸入性肝癌细胞HURP表达阳性率为19.6%。生存分析显示，HURP阳性表达(P = 0.023)、细胞学分级≥3(P = 0.008)、甲胎蛋白≥35 ng/mL(P = 0.039)、胆红素≥1.3 mg/dL(P = 0.010)、AST≥50U/L(P = 0.003)和ALT≥35U/L(P = 0.005)均与较短的无病生存期相关。逐步多因素COX比例风险模型显示，HURP阳性表达(HR，2.334；95%CI，1.165-4.679，P = 0.017)，AST≥50U/L(HR，3.697；95%CI，1.868-7.319，P<；0.001)，细胞学分级≥3(HR，4.249；95%CI，2.061-8.759，P<；0001)和肿瘤数目>；1(HR，2.633；95%CI，1.212~5.722，P = 0.014)是无病生存的独立预测因素。通过结合4个独立预测因素，不同风险评分(RS≤1与RS = 2，P = 0.001；RS = 2与RS = 3，P<；0.001)的患者显示出明显的无病生存。相反，AJCC/UICC TNM分期系统不能将患者分为预后可区分的亚组。根据吸入性肝癌细胞HURP表达、丙氨酸氨基转移酶、细胞学分级和肿瘤数目，BCLC A期肝癌患者可以分为三个预后可区分的组。
Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC). HURP expression was evaluated by immunocytochemistry of fine needle aspirated hepatoma cells in 97 HCC patients with Barcelona Clinic Liver Cancer (BCLC) stage A. Subsequently, these patients underwent partial hepatectomy (n = 18) or radiofrequency ablation (n = 79) and were followed for 2 to 35 months. The clinicopathological parameters were submitted for survival analysis. HURP expression in aspirated HCC cells was detected in 19.6% patients. Kaplan-Meier survival analysis showed that positive HURP expression (P = 0.023), cytological grading ≥3 (P = 0.008), AFP ≥35 ng/mL (P = 0.039), bilirubin ≥1.3 mg/dL (P = 0.010), AST ≥50 U/L (P = 0.003) and ALT ≥35 U/L (P = 0.005) were all associated with a shorter disease-free survival. A stepwise multivariate Cox proportional hazard model revealed that positive HURP expression (HR, 2.334; 95% CI, 1.165–4.679, P = 0.017), AST ≥50 U/L (HR, 3.697; 95% CI, 1.868–7.319, p<0.001), cytological grade ≥3 (HR, 4.249; 95% CI, 2.061–8.759, P<0.001) and tumor number >1 (HR, 2.633; 95% CI, 1.212–5.722, P = 0.014) were independent predictors for disease-free survival. By combining the 4 independent predictors, patients with different risk scores (RS) showed distinguishable disease-free survival (RS≤1 vs. RS = 2, P = 0.001; RS = 2 vs. RS = 3, P<0.001). In contrast, the patients cannot be separated into prognosis distinguishable subgroups by using AJCC/UICC TNM staging system. HCC patients with BCLC stage A can be separated into three prognosis-distinguishable groups by use of a risk score that is based upon HURP expression in aspirated HCC cells, ALT, cytological grade and tumor number.
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影响因子：
29.4
作者：
Daniele, B;Bencivenga, A;Tinessa, V
通讯作者：
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影响因子：
2.5
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DOI：
10.1111/j.1440-1746.2007.04924.x
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