Predictive Factors of HIV-1 Drug Resistance and Its Distribution among Female Sex Workers in the Democratic Republic of the Congo (DRC).
Predictive Factors of HIV-1 Drug Resistance and Its Distribution among Female Sex Workers in the Democratic Republic of the Congo (DRC).
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DOI：
10.3390/ijerph19042021
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发表时间：
2022-02-11
影响因子：
--
通讯作者：
Lusamba PD
中科院分区：
文献类型：
--
作者：
Musema GMA;Akilimali PZ;Za Balega TKN;Tshala-Katumbay D;Lusamba PD
在刚果民主共和国（DRC）的女性性工作者（FSW）中，HIV-1耐药性及其分布的预测因素记录不足。然而，预测因素的识别可以导致改进和有效的抗逆转录病毒疗法（ART）的发展。本研究的目的是确定HIV-1耐药性的预测因素及其在刚果民主共和国（DRC）研究地区的FSW分布。本研究纳入了在刚果民主共和国综合生物和行为监测调查（IBBS）中被诊断为HIV阳性的FSW。共有325名性工作者参加。根据Abbott m2000 sp和m2000 rt方案测量HIV-1病毒载量（VL）。采用卡方检验分析HIV-1耐药分布的同质性。使用0.05的显著性水平，进行多变量分析，以确定与HIV-1抗逆转录病毒药物耐药相关的因素。HIV耐药突变（HIVDRM）分布在三个研究地区是同质的（p = 0.554），但不同的基础上HIV-1 VL的FSW。与HIV-1 VL低的FSW相比，HIV-1 VL高的FSW携带更多的主要为纯HIV-1毒株的HIV-1 DRMs（p = 0.028）。性传播感染（STI）史（aOR [95%CI] = 8.51 [1.62，44.74]）、高HIV-1 VL（aOR [95%CI] = 5.39 [1.09，26.74]）和HIV-1-梅毒合并感染（aOR [95%CI] = 9.71 [1.84，51.27]）与刚果民主共和国FSW的HIV耐药相关。性传播感染史（例如，在调查前12个月，HIV-1 VL高，HIV-1-梅毒合并感染与刚果民主共和国FSW中的HIV-1耐药性有关。在HIV-1合并感染的情况下，应努力系统地检测增加HIV-1 VL的其他感染，以保持整个刚果民主共和国的抗逆转录病毒治疗效果。
The predictive factors of HIV-1 drug resistance and its distribution are poorly documented in female sex workers (FSWs) in the Democratic Republic of the Congo (DRC). However, the identification of predictive factors can lead to the development of improved and effective antiretroviral therapy (ART). The objective of the current study was to determine the predictive factors of HIV-1 drug resistance and its distribution based on FSWs in the studied regions in the Democratic Republic of the Congo (DRC). HIV-positive FSWs who were diagnosed as part of the DRC Integrated Biological and Behavioral Surveillance Survey (IBBS) were included in this study. A total of 325 FSWs participated. The HIV-1 viral load (VL) was measured according to the Abbott m2000sp and m2000rt protocols. The homogeneity chi-square test was conducted to determine the homogeneity of HIV-1 drug resistance distribution. Using a significance level of 0.05, multivariate analyses were performed to identify factors associated with HIV-1 drug resistance to ART. HIV drug resistance mutation (HIVDRM) distribution was homogeneous in the three study regions (p = 0.554) but differed based on the HIV-1 VLs of the FSWs. FSWs with high HIV-1 VLs harbored more HIVDRMs (p = 0.028) of predominantly pure HIV-1 strains compared with those that had low HIV-1 VLs. Sexually transmitted infection (STI) history (aOR [95%CI] = 8.51 [1.62, 44.74]), high HIV-1 VLs (aOR [95%CI] = 5.39 [1.09, 26.74]), and HIV-1–syphilis coinfection (aOR [95%CI] = 9.71 [1.84, 51.27]) were associated with HIV drug resistance among FSWs in the DRC. A history of STIs (e.g., abnormal fluid) in the 12 months prior to the survey, a high HIV-1 VL, and HIV-1–syphilis coinfection were associated with HIV-1 drug resistance among FSWs in the DRC. Efforts should be made to systematically test for other infections which increase the HIV-1 VL, in the case of HIV-1 coinfection, in order to maintain ART effectiveness across the DRC.
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影响因子：
8.8
作者：
Margot, Nicolas;Cox, Stephanie;Callebaut, Christian
通讯作者：
Callebaut, Christian
影响因子：
2.2
作者：
Etta, Elizabeth M.;Mavhandu, Lufuno;Tebit, Denis M.
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影响因子：
3.3
作者：
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Nsanzimana, Sabin
DOI：
10.1080/17290376.2012.743825
发表时间：
2012-09-01
影响因子：
1.1
作者：
Ngugi, E. N.;Roth, E.;Yasmin, Seema
通讯作者：
Yasmin, Seema
影响因子：
--
作者：
Atkins, MC;Carlin, EM;Boag, F
通讯作者：
Boag, F