Effect of Process Variables on the Microstructure of Hollow Hydroxyapatite Microspheres Prepared by a Glass Conversion Method.
Effect of Process Variables on the Microstructure of Hollow Hydroxyapatite Microspheres Prepared by a Glass Conversion Method.
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DOI：
10.1111/j.1551-2916.2010.03833.x
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发表时间：
2010-10-01
期刊：
影响因子：
--
通讯作者：
Day DE
中科院分区：
文献类型：
--
作者：
Fu H;Rahaman MN;Day DE
将li20 - cao - b2o3玻璃的固体微球（直径106 ~ 150 μm）在K2HPO4溶液中反应生成空心羟基磷灰石（HA）微球。研究了溶液温度（25°~ 60°C）、K2HPO4浓度（0.01 ~ 0.25 m）和pH（9 ~ 12）对空心核直径(d)与HA微球直径(d)标准化、表面积和微球壁孔径的影响。使用析因设计方法评估影响这些微观结构特征的统计显著过程变量。pH值影响不大，但溶液浓度对d/ d、表面积和孔径有显著影响，而温度对d/ d和孔径有显著影响，但对表面积无显著影响。在最低温度（25°C）或最低K2HPO4浓度（0.02M）下获得的空心芯尺寸最大（d/ d值≈0.6），而在最高浓度（0.25M）下获得的微球表面积最大（140 m2/g），孔隙尺寸为10 ~ 12 nm。讨论了这些结果对这些空心透明质酸微球作为局部递送蛋白质（如药物或生长因子）装置的潜在应用的影响。
Solid microspheres (diameter = 106–150 μm) of a Li2O–CaO–B2O3 glass were reacted in a K2HPO4 solution to form hollow hydroxyapatite (HA) microspheres. The effect of the temperature (25°–60°C), K2HPO4 concentration (0.01–0.25M), and pH (9–12) of the solution on the diameter (d) of the hollow core normalized to the diameter (D) of the HA microspheres, the surface area, and the pore size of the microsphere wall was studied. The statistically significant process variables that influenced these microstructural characteristics were evaluated using a factorial design approach. While the pH had little effect, the concentration of the solution had a marked effect on d/D, surface area, and pore size, whereas temperature markedly influenced d/D and pore size, but not the surface area. The largest hollow core size (d/D value ≈ 0.6) was obtained at the lowest temperature (25°C) or the lowest K2HPO4 concentration (0.02M), while microspheres with the highest surface area (140 m2/g), with pores of size 10–12 nm were obtained at the highest concentration (0.25M). The consequences of these results for potential application of these hollow HA microspheres as devices for local delivery of proteins, such as drugs or growth factors, are discussed.
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DOI：
10.4028/www.scientific.net/kem.309-311.65
发表时间：
2006-01-01
期刊：
BIOCERAMICS 18, PTS 1 AND 2
影响因子：
--
作者：
Peng, Q;Ming, L;Weng, J
通讯作者：
Weng, J
影响因子：
3.5
作者：
VERHOEF, AH;DENHARTOG, HW
通讯作者：
DENHARTOG, HW
影响因子：
3.6
作者：
ONO, I;OHURA, T;KUBOKI, Y
通讯作者：
KUBOKI, Y
影响因子：
3.5
作者：
VERHOEF, AH;DENHARTOG, HW
通讯作者：
DENHARTOG, HW
影响因子：
3.6
作者：
RIPAMONTI, U;MA, SS;REDDI, AH
通讯作者：
REDDI, AH