High b value (2,000 s/mm2) diffusion-weighted magnetic resonance imaging in prostate cancer at 3 Tesla: comparison with 1,000 s/mm2 for tumor conspicuity and discrimination of aggressiveness.
High b value (2,000 s/mm2) diffusion-weighted magnetic resonance imaging in prostate cancer at 3 Tesla: comparison with 1,000 s/mm2 for tumor conspicuity and discrimination of aggressiveness.
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DOI：
10.1371/journal.pone.0096619
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Tamada T;Kanomata N;Sone T;Jo Y;Miyaji Y;Higashi H;Yamamoto A;Ito K
本研究的目的是探讨在3-T高B值扩散加权磁共振成像（DW-MRI）上肿瘤的显著性和对肿瘤侵袭性的辨别潜力。机构审查委员会批准了本研究，并免除了知情同意的要求。共纳入了50例前列腺癌患者（69个癌灶; 48个在PZ，20个在TZ，1个在整个前列腺），这些患者在3-T系统上接受了多参数前列腺MRI，包括DW-MRI（B值：0，1000 s/mm 2和0，2000 s/mm 2）。采用视觉评估法（1 =周围正常部位不可见; 2 =稍高强度; 3 =中等强度; 4 =非常高）评估病变显著性评分（LCS）和肿瘤-正常信号强度比（TNR），并测量肿瘤区域和正常区域的表观扩散系数（ADC，×10−3 mm 2/s）。 0，2000 s/mm 2时的平均LCS和TNR显著高于0，1000 s/mm 2时的平均LCS和TNR（两者均为p<0.001）。此外，发现在0，1000和0，2000 s/mm 2下的ADC可区分Gleason评分≥7的中危或高危癌症与Gleason评分≤6的低危癌症（两者均为p<0.001）。此外，肿瘤区域的ADC值与Gleason评分在0，1000 s/mm 2（ρ = −0.602; p<0.001）和0，2000 s/mm 2（ρ = −0.645; p<0.001）时均相关。 对于前列腺癌在3-T MRI的DW-MRI上的肿瘤显著性和表征，B = 0，2000 s/mm 2比B = 0，1000 s/mm 2更有用。
The objective of our study was to investigate tumor conspicuity and the discrimination potential for tumor aggressiveness on diffusion-weighted magnetic resonance imaging (DW-MRI) with high b value at 3-T. The institutional review board approved this study and waived the requirement for informed consent. A total of 50 patients with prostate cancer (69 cancer foci; 48 in the PZ, 20 in the TZ, and one in whole prostate) who underwent multiparametric prostate MRI including DW-MRI (b values: 0, 1000 s/mm2 and 0, 2000 s/mm2) on a 3-T system were included. Lesion conspicuity score (LCS) using visual assessment (1 = invisible for surrounding normal site; 2 = slightly high intensity; 3 = moderately high; and 4 = very high) and tumor-normal signal intensity ratio (TNR) were assessed, and apparent diffusion coefficient (ADC, ×10−3 mm2/s) of the tumor regions and normal regions were measured. Mean LCS and TNR at 0, 2000 s/mm2 was significantly higher than those at 0, 1000 s/mm2 (p<0.001 for both). In addition, ADC at both 0, 1000 and 0, 2000 s/mm2 was found to distinguish intermediate or high risk cancer with Gleason score ≥7 from low risk cancer with Gleason score ≤6 (p<0.001 for both). Furthermore, ADC of tumor regions correlated with Gleason score at both 0, 1000 s/mm2 (ρ = −0.602; p<0.001) and 0, 2000 s/mm2 (ρ = −0.645; p<0.001). For tumor conspicuity and characterization of prostate cancer on DW-MRI of 3-T MRI, b = 0, 2000 s/mm2 is more useful than b = 0, 1000 s/mm2.
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影响因子：
19.7
作者：
Kaji, Y;Kurhanewicz, J;Vigneron, DB
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