Recursive Partitioning Analysis of Fractional Low-Frequency Fluctuations in Narcolepsy With Cataplexy.
Recursive Partitioning Analysis of Fractional Low-Frequency Fluctuations in Narcolepsy With Cataplexy.
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发作性睡病伴猝倒的分数低频波动的递归分区分析。
DOI：
10.3389/fneur.2018.00936
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发表时间：
2018
影响因子：
3.4
通讯作者：
Fang H
中科院分区：
文献类型：
--
作者：
Fulong X;Chao L;Dianjiang Z;Qihong Z;Wei Z;Jun Z;Fang H
目的：与健康对照组比较，确定发作性睡病相关的局部脑活动改变。通过递归分割分析（RPA）和受试者工作特征（ROC）曲线分析，确定这些变化是否可用于区分发作性睡病和健康对照。方法：招募了51名发作性睡病患者（26名成人和25名青少年）和60名匹配的健康对照（30名成人和30名青少年）。所有受试者均接受静息状态功能性磁共振成像扫描。采用分数低频波动（fALFF）方法研究了发作性睡病引起的成年和青少年脑局部活动的变化。使用递归分割分析和接收者操作曲线分析来寻求脑区域内的fALFF值区分发作性睡病与健康对照的能力。结果如下：与健康对照组相比，成人和青少年发作性睡病患者双侧额内侧上级回、双侧顶下小叶和缘上回的fALFF值均较低。与健康对照组相比，成人和青少年发作性睡病患者双侧感觉运动皮层和颞中回的fALFF值均较高。青少年嗜睡症患者右侧壳核和右侧丘脑的fALFF也高于健康对照组。基于RPA和ROC曲线分析，在成年受试者中，右侧内侧上级额上回的fALFF差异可以区分发作性睡病和健康对照，具有高度的敏感性（100%）和特异性（88.9%）。在青少年受试者中，左额上级回的fALFF差异可以区分发作性睡病与健康对照组，具有中等程度的敏感性（57.1%）和特异性（88.9%）。结论：与健康对照组比较，成人和青少年发作性睡病患者的fALFF差异均表现出重叠的脑区。此外，我们建议fALFF值可以是一个有用的成像生物标志物，在区分嗜睡症从健康对照成人和青少年。
Objective: To identify narcolepsy related regional brain activity alterations compared with matched healthy controls. To determine whether these changes can be used to distinguish narcolepsy from healthy controls by recursive partitioning analysis (RPA) and receiver operating characteristic (ROC) curve analysis. Method: Fifty-one narcolepsy with cataplexy patients (26 adults and 25 juveniles) and sixty matched heathy controls (30 adults and 30 juveniles) were recruited. All subjects underwent a resting-state functional magnetic resonance imaging scan. Fractional low-frequency fluctuations (fALFF) was used to investigate narcolepsy induced regional brain activity alterations among adult and juveniles, respectively. Recursive partitioning analysis and Receiver operating curve analysis was used to seek the ability of fALFF values within brain regions in distinguishing narcolepsy from healthy controls. Results: Compared with healthy controls, both adult and juvenile narcolepsy had lower fALFF values in bilateral medial superior frontal gyrus, bilateral inferior parietal lobule and supra-marginal gyrus. Compared with healthy controls, both adult and juvenile narcolepsy had higher fALFF values in bilateral sensorimotor cortex and middle temporal gyrus. Also juvenile narcolepsy had higher fALFF in right putamen and right thalamus compared with healthy controls. Based on RPA and ROC curve analysis, in adult participants, fALFF differences in right medial superior frontal gyrus can discriminate narcolepsy from healthy controls with high degree of sensitivity (100%) and specificity (88.9%). In juvenile participants, fALFF differences in left superior frontal gyrus can discriminate narcolepsy from healthy controls with moderate degree of sensitivity (57.1%) and specificity (88.9%). Conclusion: Compared with healthy controls, both the adult and juvenile narcolepsy showed overlap brain regions in fALFF differences after case-control comparison. Furthermore, we propose that fALFF value can be a helpful imaging biomarker in distinguishing narcolepsy from healthy controls among both adults and juveniles.
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