Excess deaths among adults with sickle cell disease in 2020 compared to prior years.
Excess deaths among adults with sickle cell disease in 2020 compared to prior years.
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DOI：
10.1007/s00277-022-04994-6
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发表时间：
2023-01
影响因子：
3.5
通讯作者：
Caterina M
中科院分区：
文献类型：
--
作者：
Curtis S;Henny B;Joanna S;Betancourt J;Thomas M;Vattappally L;Crouch A;Caterina M
2020年，由于COVID感染，美国的超额死亡人数增加了20%，这也是由于大流行导致的医疗系统变化。我们假设患有镰状细胞病（SCD）的人可能容易受到这些变化的影响，因为SCD可导致快速失代偿。我们检查了2020年在我们中心死亡的所有SCD患者。确定死亡原因、临床变量和医疗保健利用情况，并从电子病历中获取死亡事件中是否存在COVID感染、败血症和急性器官衰竭。将2020年的死亡人数与2017-2019年的死亡人数进行比较。2020年，死亡人数增加244%（22人对9人），但在2020年的死亡人数中，只有36%的人被确诊为急性或既往感染。与前几年相比，2020年死亡的人更有可能在死亡事件中发生急性器官衰竭（70.6% vs 21.1%, p = 0.003）。他们也更有可能有中风史，更频繁地去血液科诊所就诊。与前几年相比，2020年的死亡人数翻了一番，COVID感染并不能解释所有这些超额死亡率。2020年死亡的人可能患有更严重的疾病，这表明他们有更多的诊所就诊和更高的中风率，并且在死亡事件中更有可能发生器官衰竭。这表明患有SCD的人可能特别容易受到护理延误的影响。应该进行更大规模的多中心研究来进一步研究这一点。在线版本包含补充材料，可在10.1007/s00277-022-04994-6获得。
In 2020, there was a 20% increase in excess deaths in the USA due to COVID infections but also to changes in the healthcare system due to the pandemic. We hypothesized that people living with sickle cell disease (SCD) may be vulnerable to these changes as SCD can lead to rapid decompensation. We examined all deaths of people with SCD at our center in 2020. Cause of death was determined, clinical variables, and healthcare utilization, and the presence of COVID infection, sepsis, and acute organ failure during the death event was obtained from the electronic medical record. Deaths in 2020 were compared to deaths in 2017–2019. In 2020, deaths increase 244% (22 vs 9), but acute or previous COVID infections were identified in only 36% of 2020 deaths. People who died in 2020 were more likely to have developed acute organ failure during the death event (70.6% vs 21.1%, p = 0.003) compared to prior years. They were also more likely to have a history of stroke and more frequent hematology clinic visits. Deaths in 2020 doubled compared to prior years and COVID infection could not account for all of this excess mortality. People who died in 2020 may have had more severe disease as suggested by having more clinic visits and higher rates of stroke and were more likely to develop organ failure during the death event. This demonstrates that people with SCD may be especially vulnerable to delays in care. Larger multicenter studies should be conducted to examine this further. The online version contains supplementary material available at 10.1007/s00277-022-04994-6.
影响因子：
7.5
作者：
Mucalo L;Brandow AM;Dasgupta M;Mason SF;Simpson PM;Singh A;Taylor BW;Woods KJ;Yusuf FI;Panepinto JA
通讯作者：
Panepinto JA
与其他黑人个体相比，患有镰状细胞病/性状的个体中的 COVID-19。
影响因子：
7.5
作者：
Singh A;Brandow AM;Panepinto JA
通讯作者：
Panepinto JA
影响因子：
7.5
作者：
Minniti CP;Zaidi AU;Nouraie M;Manwani D;Crouch GD;Crouch AS;Callaghan MU;Carpenter S;Jacobs C;Han J;Simon J;Glassberg J;Gordeuk VR;Klings ES
通讯作者：
Klings ES