TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
复制标题
TERT 多态性 rs2853669 对韩国人群肺癌风险的影响
DOI：
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发表时间：
2015
影响因子：
4.5
通讯作者：
J. Park
中科院分区：
文献类型：
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作者：
S. Yoo;S. K. Do;J. Choi;Shin‐Yup Lee;Jaehee Lee;S. Cha;C. Kim;J. Park
短端粒被认为是人类癌症的危险因素之一。本研究使用1，100例病例和1，096例对照来评估韩国人群中与短端粒长度相关的6种多态性与肺癌风险之间的关联。在隐性模型下，6个多态性中，TERTrs 2853669与肺癌风险增加显著相关（OR =1.38，95%可信区间CI =1.05-1.81，P=0.02）。rs 2853669对年轻个体（OR=1.73，95%CI =1.18-2.54，P=0.005）和腺癌（OR=1.50，95%CI =1.07-2.07，P=0.02）的肺癌风险有显著影响。我们的研究结果表明，一个共同的功能性启动子多态性，TERTrs 2853669，可能会影响端粒长度和肺癌的风险在韩国人口。图形摘要
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population. Graphical Abstract
DOI：
10.1093/jnci/djg011
发表时间：
2003-08-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
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作者：
Wu, XF;Amos, CI;Spitz, MR
通讯作者：
Spitz, MR