Impact of Obesity on Anti-Mullerian Hormone (AMH) Levels in Women of Reproductive Age.
Impact of Obesity on Anti-Mullerian Hormone (AMH) Levels in Women of Reproductive Age.
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DOI：
10.3390/jcm10143192
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发表时间：
2021-07-20
影响因子：
3.9
通讯作者：
Lujan ME
中科院分区：
文献类型：
--
作者：
Oldfield AL;Kazemi M;Lujan ME
肥胖对生殖健康有负面影响，包括卵巢功能。肥胖已被假定为改变抗苗勒管激素（AMH）的生产。了解可能影响AMH水平的生物学因素是必要的，因为越来越多的人使用AMH来预测控制性卵巢刺激后的生殖健康结果，诊断排卵障碍，绝经期的开始和自然受孕。在这篇叙述性综述中，我们评估了肥胖对健康、定期骑自行车的育龄妇女（18-48岁）AMH水平的影响。纳入了13项研究（n = 1214名女性;（811，非肥胖（体重指数; BMI < 30 kg/m2）; 403，肥胖（BMI > 30 kg/m2），其中5项报告了肥胖导致AMH水平下降，而8项研究显示各组之间AMH水平相当。纳入肥胖程度较高的女性（3级与1级）可能是研究报告AMH水平较低的一个因素。总之，研究报告AMH水平在其他健康的妇女仍然受到小样本量，横断面设计，并缺乏代表性，在整个肥胖症谱的限制。最终，肥胖可能对AMH水平产生负面影响的程度，以及可能的卵巢储备，在月经周期规律的健康女性中，目前应被视为不确定。考虑到肥胖对AMH产生影响的生物学基础尚不清楚，这一结论是谨慎的。
Obesity negatively impacts reproductive health, including ovarian function. Obesity has been posited to alter Anti-Müllerian hormone (AMH) production. Understanding biological factors that could impact AMH levels is necessary given the increasing use of AMH for predicting reproductive health outcomes in response to controlled ovarian stimulation, diagnosing ovulatory disorders, onset of menopause, and natural conception. In this narrative review, we evaluated the impact of obesity on AMH levels in healthy, regularly cycling reproductive-age women (18–48 years). Thirteen studies (n = 1214 women; (811, non-obese (body mass index; BMI < 30 kg/m2); 403, obese (BMI > 30 kg/m2))) were included, of which five reported decreased AMH levels with obesity, whereas eight showed comparable AMH levels between groups. Inclusion of women with higher obesity classes (Class 3 versus Class 1) may have been a factor in studies reporting lower AMH levels. Together, studies reporting AMH levels in otherwise healthy women remain limited by small sample sizes, cross-sectional designs, and lack of representation across the entire adiposity spectrum. Ultimately, the degree to which obesity may negatively impact AMH levels, and possibly ovarian reserve, in otherwise healthy women with regular menstrual cycles should be deemed uncertain at this time. This conclusion is prudent considering that the biological basis for an impact of obesity on AMH production is unknown.
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影响因子：
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