Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation.
Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation.
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DOI：
10.1016/j.neuropharm.2013.05.042
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发表时间：
2014-01
影响因子：
4.7
通讯作者：
Markou A
中科院分区：
文献类型：
--
作者：
Li X;Semenova S;D'Souza MS;Stoker AK;Markou A
尽管公众已经充分认识到吸烟的有害后果，但吸烟仍然是全球主要的健康危害。虽然目前有几种戒烟治疗方案，但这些药物仅对一小部分吸烟者有效，复发率仍然很高。因此，更好地了解介导烟草依赖的神经生物学机制对于开发有效的戒烟药物至关重要。尼古丁是烟草中主要的精神活性成分，导致有害的吸烟习惯。尼古丁与大脑中的烟碱乙酰胆碱受体（nAChRs）结合，导致释放多种神经递质，包括谷氨酸和γ-氨基丁酸（GABA）。本文就兴奋性谷氨酸系统和抑制性GABA系统在尼古丁依赖中的作用作一综述。越来越多的证据表明，阻断谷氨酸能传递或促进gaba能传递会减弱尼古丁的积极强化和激励动机方面，抑制尼古丁的奖励增强和条件奖励作用，并阻断尼古丁寻求行为。慢性尼古丁暴露产生长期的神经适应，有助于尼古丁戒断，但GABA和谷氨酸在尼古丁戒断中的作用尚不清楚。总的来说，本综述的发现为谷氨酸能和gaba能药物治疗尼古丁依赖和尼古丁戒断的潜在有效性提供了强有力的证据。
Tobacco smoking continues to be a major global health hazard despite significant public awareness of its harmful consequences. Although several treatment options are currently available for smoking cessation, these medications are effective in only a small subset of smokers, and relapse rates continue to be high. Therefore, a better understanding of the neurobiological mechanisms that mediate tobacco dependence is essential for the development of effective smoking cessation medications. Nicotine is the primary psychoactive component of tobacco that drives the harmful tobacco smoking habit. Nicotine binds to nicotinic acetylcholine receptors (nAChRs) in the brain, resulting in the release of a wide range of neurotransmitters, including glutamate and γ-aminobutyric acid (GABA). This review article focuses on the role of the excitatory glutamate system and inhibitory GABA system in nicotine dependence. Accumulating evidence suggests that blockade of glutamatergic transmission or facilitation of GABAergic transmission attenuates the positive reinforcing and incentive motivational aspects of nicotine, inhibits the reward-enhancing and conditioned rewarding effects of nicotine, and blocks nicotine-seeking behavior. Chronic nicotine exposure produced long-term neuroadaptations that contribute to nicotine withdrawal, but the role of GABA and glutamate transmission in nicotine withdrawal is less understood. Overall, the findings presented in this review provide strong converging evidence for the potential effectiveness of glutamatergic and GABAergic medications in nicotine dependence and potentially nicotine withdrawal.
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影响因子：
4.7
作者：
Chaki, S;Yoshikawa, R;Nakazato, A
通讯作者：
Nakazato, A
影响因子：
4.7
作者：
Brown, Richard A.;Lejuez, C. W.;Price, Lawrence H.
通讯作者：
Price, Lawrence H.
DOI：
10.1038/npp.2011.299
发表时间：
2012-04
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6
作者：
Agrawal, Arpana;Pergadia, Michele L.;Madden, Pamela A. F.
通讯作者：
Madden, Pamela A. F.
影响因子：
7.6
作者：
Bruijnzeel, Adrie W.;Zislis, George;Gold, Mark S.
通讯作者：
Gold, Mark S.