Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.
Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.
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DOI：
10.1111/1462-2920.13897
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发表时间：
2017-10
影响因子：
5.1
通讯作者：
Newman SA
中科院分区：
文献类型：
--
作者：
Cabello FC;Godfrey HP;Bugrysheva JV;Newman SA
莱姆病的病因伯氏疏螺旋体感染在北美和欧洲是一个日益严重的公共卫生问题。这些螺旋体能够在它们的壁虱媒介和脊椎动物储存库中维持较长时间的能力，对于地方病循环的持续以及人类对它们的暴露是至关重要的。由警报蛋白(P)ppGpp介导的严格反应已被确定为伯氏杆菌的主要调控因子。它调节已识别和未识别的开放阅读框架的表达，这些开放阅读框架需要处理和克服扁虱和动物水库中的螺旋体所面临的许多营养压力和其他挑战。伯氏杆菌严格反应的激活所引起的代谢和形态变化也可能与最近描述的对致死剂量的抗菌剂和其他抗菌活性耐受的非遗传表型现象有关。因此，它可能在莱姆病疏螺旋体感染的多个方面构成关键，在其地方性生命周期的微生态挑战和在其动物宿主组织中的长期居住之间提供联系，以及可能在偶然的人类宿主中持续存在的进化副作用。
Infections with tick-transmitted Borreliella (Borrelia) burgdorferi, the cause of Lyme disease, represent an increasingly large public health problem in North America and Europe. The ability of these spirochetes to maintain themselves for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for continuance of the enzootic cycle as well as for the increasing exposure of humans to them. The stringent response mediated by the alarmone (p)ppGpp has been determined to be a master regulator in B. burgdorferi. It modulates the expression of identified and unidentified open reading frames needed to deal with and overcome the many nutritional stresses and other challenges faced by the spirochete in ticks and animal reservoirs. The metabolic and morphologic changes resulting from activation of the stringent response in B. burgdorferi may also be involved in the recently described non-genetic phenotypic phenomenon of tolerance to otherwise lethal doses of antimicrobials and to other antimicrobial activities. It may thus constitute a linchpin in multiple aspects of infections with Lyme disease borrelia, providing a link between the micro-ecological challenges of its enzootic life-cycle and long-term residence in the tissues of its animal reservoirs, with the evolutionary side-effect of potential persistence in incidental human hosts.
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影响因子：
16
作者：
Amato, Stephanie M.;Orman, Mehmet A.;Brynildsen, Mark P.
通讯作者：
Brynildsen, Mark P.
影响因子：
2.8
作者：
Alban, PS;Johnson, PW;Nelson, DR
通讯作者：
Nelson, DR
影响因子：
14.9
作者：
Adams PP;Flores Avile C;Popitsch N;Bilusic I;Schroeder R;Lybecker M;Jewett MW
通讯作者：
Jewett MW
影响因子：
3.1
作者：
Azriel, Shalhevet;Goren, Alina;Gal-Mor, Ohad
通讯作者：
Gal-Mor, Ohad
影响因子：
3.1
作者：
Bockenstedt, LK;Kang, I;Barthold, SW
通讯作者：
Barthold, SW