Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala.
Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala.
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DOI：
10.1038/npp.2010.246
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发表时间：
2011-04
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Central among the brain regions that regulate fear/anxiety behaviors is the lateral/basolateral amygdala (BLA). BLA output is tightly controlled by the relative activity of two populations of inhibitory GABAergic interneurons, local feed-back cells distributed throughout the nucleus and feed-forward cells found along the lateral paracapsular border of this subdivision. Recent studies suggest that dopamine can modulate the BLA GABAergic system thus linking fear/anxiety-states with mesolimbic reward/attentional processes. However, the precise dopaminergic mechanisms regulating the activity of the two BLA GABAergic neuron populations have not been fully explored. We therefore examined the effects of dopamine (DA) D3-like receptors on BLA-dependent anxiety-like behavior and neurophysiology. After confirming the presence of D3-like receptors within the BLA, we found that microinjection of a D3-selective antagonist into the BLA decreased anxiety-like behavior expressed in both the light/dark transition test and the elevated plus maze. Consistent with this, we found that in vitro D3-like receptor activation selectively inhibits synaptic transmission at both BLA feed-back and feed-forward GABAergic interneuron populations, with no effect on glutamatergic transmission. This inhibition of GABAergic transmission is a result of a D3-like receptor-mediated, dynamin-dependent process that presumably reflects endocytosis of postsynaptic GABAA receptors found on principal BLA neurons. Because environmental cues alter both DA release and relative activity states of the BLA, our data strongly suggest that DA, potentially acting through D3-like receptors, may suppress the relative contribution by inhibitory processes in the BLA and modify the expression of BLA-related behaviors.
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影响因子：
25
作者：
Kienast, Thorsten;Hariri, Ahmad R.;Heinz, Andreas
通讯作者：
Heinz, Andreas
影响因子：
2.9
作者：
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Botting, SK
影响因子：
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作者：
Marowsky, A;Yanagawa, Y;Vogt, KE
通讯作者：
Vogt, KE
DOI：
10.1124/jpet.105.100552
发表时间：
2006-08-01
影响因子：
3.5
作者：
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通讯作者：
McCool, Brian A.
影响因子：
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作者：
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通讯作者：
WIGHTMAN, RM