An update on vinpocetine: New discoveries and clinical implications.
An update on vinpocetine: New discoveries and clinical implications.
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DOI：
10.1016/j.ejphar.2017.11.041
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发表时间：
2018-01-15
影响因子：
5
通讯作者：
Yan C
中科院分区：
文献类型：
--
作者：
Zhang YS;Li JD;Yan C
长春新碱是长春胺生物碱的衍生物，30多年来在许多国家临床上用于治疗脑血管疾病，如中风和痴呆。目前，长春新碱也可在市场上作为膳食补充剂，以提高认知和记忆。由于其优异的安全性，人们越来越多地致力于探索长春新碱在各种细胞类型和疾病模型中的新的治疗效果和作用机制。近年来的研究发现长春新碱具有抗炎、抗损伤性血管重构、抗高脂饮食诱导的动脉粥样硬化以及减轻病理性心脏重构等作用。这些新发现可能有助于重新定位长春新碱，以预防或治疗人类相关疾病。
Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory. Due to its excellent safety profile, increasing efforts have been put into exploring the novel therapeutic effects and mechanism of actions of vinpocetine in various cell types and disease models. Recent studies have revealed a number of novel functions of vinpocetine, including anti-inflammation, antagonizing injury-induced vascular remodeling and high-fat-diet-induced atherosclerosis, as well as attenuating pathological cardiac remodeling. These novel findings may facilitate the repositioning of vinpocetine for preventing or treating relevant disorders in humans.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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作者：
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