Chemistry towards Biology-Instruct: Snapshot.

Chemistry towards Biology-Instruct: Snapshot.
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DOI:
10.3390/ijms232314815
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发表时间:
2022-11-26
影响因子:
5.6
通讯作者:
Jampilek, Josef
Jampilek, Josef
中科院分区:
生物学2区
文献类型:
--
作者:
Hricovini, Milos;Owens, Raymond J.;Bak, Andrzej;Kozik, Violetta;Musial, Witold;Pierattelli, Roberta;Majekova, Magdalena;Rodriguez, Yoel;Musiol, Robert;Slodek, Aneta;Starha, Pavel;Pietak, Karina;Slota, Dagmara;Florkiewicz, Wioletta;Sobczak-Kupiec, Agnieszka;Jampilek, Josef

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不同分子之间相互作用的知识无疑是所有当代生物医学和生物科学的驱动力。化学生物学/生物化学已成为一个重要的多学科桥梁,连接化学和生物学的观点,研究小分子/肽模拟物及其在生物系统中的相互作用。结构生物学研究的进展,特别是将原子结构与分子特性和细胞环境联系起来,对于复杂设计具有高度可药用性和非常重要的药物相似性的新药至关重要。该贡献的作者是该领域的杰出科学家,他们简要概述了他们的工作,从计算机研究到化合物与生物分子的相互作用的表征,再到生物活性材料。
The knowledge of interactions between different molecules is undoubtedly the driving force of all contemporary biomedical and biological sciences. Chemical biology/biological chemistry has become an important multidisciplinary bridge connecting the perspectives of chemistry and biology to the study of small molecules/peptidomimetics and their interactions in biological systems. Advances in structural biology research, in particular linking atomic structure to molecular properties and cellular context, are essential for the sophisticated design of new medicines that exhibit a high degree of druggability and very importantly, druglikeness. The authors of this contribution are outstanding scientists in the field who provided a brief overview of their work, which is arranged from in silico investigation through the characterization of interactions of compounds with biomolecules to bioactive materials.
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