Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity.
Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity.
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DOI：
10.1371/journal.pone.0018350
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发表时间：
2011-04-13
期刊：
影响因子：
3.7
通讯作者：
Pak TR
中科院分区：
文献类型：
--
作者：
Przybycien-Szymanska MM;Mott NN;Paul CR;Gillespie RA;Pak TR
青春期是大脑发育的动态和重要时期，然而，对青春期饮酒的长期神经生物学后果知之甚少。我们以前的研究表明，在青春期发育过程中，酗酒模式乙醇（EtOH）治疗负失调的下丘脑-垂体-肾上腺（HPA）轴的反应，表现为在此期间的促肾上腺皮质激素释放激素（CRH），精氨酸加压素（AVP），皮质酮（CORT）的改变。因此，本研究的主要目的是确定这些观察到的应激反应的重要中枢调节因子的变化是永久性的还是暂时性的。在这项研究中，幼年雄性Wistar大鼠用暴食模式EtOH处理范例或单独用盐水处理8天。动物不受干扰，直到成年，然后接受第二轮治疗，包括单独的盐水、单剂量的EtOH或第二次暴食模式治疗范例。结果表明，青春期酒精暴露可引起HPA轴多项参数的显著、持久的改变。总的来说，我们的数据提供了强有力的证据，表明青春期成熟期间的酒精暴露对HPA轴的健康发育有长期的不利影响。
Adolescence is a dynamic and important period of brain development however, little is known about the long-term neurobiological consequences of alcohol consumption during puberty. Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period. Thus, the primary goal of this study was to determine whether these observed changes in important central regulators of the stress response were permanent or transient. In this study, juvenile male Wistar rats were treated with a binge-pattern EtOH treatment paradigm or saline alone for 8 days. The animals were left undisturbed until adulthood when they received a second round of treatments consisting of saline alone, a single dose of EtOH, or a second binge-pattern treatment paradigm. The results showed that pubertal binge-pattern EtOH exposure induced striking long-lasting alterations of many HPA axis parameters. Overall, our data provide strong evidence that binge-pattern EtOH exposure during pubertal maturation has long-term detrimental effects for the healthy development of the HPA axis.
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