The Drosophila melanogaster Genetic Reference Panel.
The Drosophila melanogaster Genetic Reference Panel.
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DOI：
10.1038/nature10811
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发表时间：
2012-02-08
期刊：
影响因子：
64.8
通讯作者：
Gibbs, Richard A.
中科院分区：
文献类型：
--
作者：
Mackay, Trudy F. C.;Richards, Stephen;Stone, Eric A.;Barbadilla, Antonio;Ayroles, Julien F.;Zhu, Dianhui;Casillas, Sonia;Han, Yi;Magwire, Michael M.;Cridland, Julie M.;Richardson, Mark F.;Anholt, Robert R. H.;Barron, Maite;Bess, Crystal;Blankenburg, Kerstin Petra;Carbone, Mary Anna;Castellano, David;Chaboub, Lesley;Duncan, Laura;Harris, Zeke;Javaid, Mehwish;Jayaseelan, Joy Christina;Jhangiani, Shalini N.;Jordan, Katherine W.;Lara, Fremiet;Lawrence, Faye;Lee, Sandra L.;Librado, Pablo;Linheiro, Raquel S.;Lyman, Richard F.;Mackey, Aaron J.;Munidasa, Mala;Muzny, Donna Marie;Nazareth, Lynne;Newsham, Irene;Perales, Lora;Pu, Ling-Ling;Qu, Carson;Ramia, Miquel;Reid, Jeffrey G.;Rollmann, Stephanie M.;Rozas, Julio;Saada, Nehad;Turlapati, Lavanya;Worley, Kim C.;Wu, Yuan-Qing;Yamamoto, Akihiko;Zhu, Yiming;Bergman, Casey M.;Thornton, Kevin R.;Mittelman, David;Gibbs, Richard A.
生物学的一个主要挑战是了解分子遗传变异和数量性状变异之间的关系，包括健身。这种关系决定了我们从基因型中预测表型的能力，以及理解进化力量如何塑造物种内部和物种之间的变异。以前的努力剖析基因型-表型图是基于不完整的基因型信息。在这里，我们描述了果蝇遗传参考面板（DGRP），群体基因组学和数量性状分析的社区资源。DGRP由来自自然群体的完全测序的近交系组成。群体基因组分析显示着丝粒常染色体区域和X染色体的多态性减少，阳性和阴性选择的证据，以及X染色体的快速进化。新基因中的许多变异（大多数频率较低）与数量性状相关，并解释了大部分表型变异。DGRP利用果蝇遗传学的力量促进基因型-表型作图。
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.
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影响因子：
64.8
作者：
Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
通讯作者：
MacCallum, Iain
影响因子：
64.8
作者：
Fay, JC;Wyckoff, GJ;Wu, CI
通讯作者：
Wu, CI
影响因子：
30.8
作者：
Ayroles, Julien F.;Carbone, Mary Anna;Stone, Eric A.;Jordan, Katherine W.;Lyman, Richard F.;Magwire, Michael M.;Rollmann, Stephanie M.;Duncan, Laura H.;Lawrence, Faye;Anholt, Robert R. H.;Mackay, Trudy F. C.
通讯作者：
Mackay, Trudy F. C.
影响因子：
10.7
作者：
Eyre-Walker, Adam;Keightley, Peter D.
通讯作者：
Keightley, Peter D.
影响因子：
10.7
作者：
Casillas, Sonia;Barbadilla, Antonio;Bergman, Casey M.
通讯作者：
Bergman, Casey M.