Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development
Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development
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果蝇 jumu 通过 JNK 依赖性途径调节细胞凋亡，并且是翅膀发育中其他过程所必需的
DOI：
10.1007/s10495-019-01527-x
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发表时间：
2019-02
期刊：
影响因子：
7.2
通讯作者：
Jin Li Hua
中科院分区：
文献类型：
--
作者：
Wang Xiao Chun;Liu Ziguang;Jin Li Hua
Previous studies in several model organisms have revealed that members of the Forkhead (Fkh) transcription factor family have multiple functions. Drosophila Jumeau (Jumu), a member of this family, participates in cardiogenesis, hematopoiesis and immune system homeostasis. Here, we show that loss of jumu function positively regulates or triggers apoptosis via a JNK-dependent pathway in wing development. jumu mutants showed reduced wing size and increased apoptosis. Moreover, we observed a loss of the anterior cross vein (ACV) phenotype that was similar to that observed in wings in which JNK signaling has been ectopically activated. The JNK signaling markers puckered (puc) and p-JNK were also significantly increased in the wing discs of jumu mutants. In addition, apoptosis induced by the loss of jumu was rescued by knocking down JNK, indicating a role for JNK in reducing jumu-induced apoptosis. Jumu could also control wing margin development via the positive regulation of cut expression, and the observed wing margin defect did not result from a loss of jumu-induced apoptosis. Further, jumu deficiency in the pupal wing could induce multiple wing hairs via a Rho1-mediated planar cell polarity pathway, but abnormal Rho1 expression was not why jumu loss induced apoptosis via a JNK-dependent pathway in wing discs.
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