Localized JNK signaling regulates organ size during development
Localized JNK signaling regulates organ size during development
复制标题
局部 JNK 信号传导在发育过程中调节器官大小
作者：
Willsey Helen Rankin;Zheng Xiaoyan;Pastor-Pareja Jose Carlos;Willsey A. Jeremy;Beachy Philip A.;Xu Tian
Studies in mice and humans have demonstrated a role for the immune system in preventing the growth of tumors. Deciphering the mechanisms involved in the immune response to tumors is essential to our understanding of immune recognition and cancer progression. Here we report an innate immune response to tumors in Drosophila melanogaster. We found that circulating blood cells, termed hemocytes, adhere to tumors upon detection of basement membrane disruption, and subsequently counter their growth. Basement membrane components are remarkably conserved throughout the animal kingdom, providing a unique structure for the immune system to sense tissue integrity. Further, we show that tissue damage activates JNK signaling in both tumors and aseptic wounds, causing expression of JAK/STAT-activating cytokines. Cytokine secretion from the injured tissue is amplified into a systemic response through the induction of additional cytokine expression in the hemocytes and the fat body, resulting in hemocyte proliferation. Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans.
登录
查看更多内容
影响因子：
14.9
作者：
Audrey Kauffmann;R. Gentleman;W. Huber
通讯作者：
Audrey Kauffmann;R. Gentleman;W. Huber
DOI：
--
发表时间：
1993
期刊：
Development (Cambridge, England). Supplement
影响因子：
--
作者：
J. Ring;A. Martinez Arias
通讯作者：
J. Ring;A. Martinez Arias
影响因子：
12.4
作者：
MacDonald, J. M.;Doherty, J.;Freeman, M. R.
通讯作者：
Freeman, M. R.
影响因子：
4.6
作者：
Oh, Hyangyee;Irvine, Kenneth D.
通讯作者：
Irvine, Kenneth D.
影响因子：
4.6
作者：
Myriam Zecca;K. Basler;G. Struhl
通讯作者：
Myriam Zecca;K. Basler;G. Struhl