Inhibition of microtubule polymerization by SK&F 96365, a blocker of receptor-linked Ca2+ entry.
Inhibition of microtubule polymerization by SK&F 96365, a blocker of receptor-linked Ca2+ entry.
复制标题
SK 对微管聚合的抑制
DOI：
10.1254/jjp.82.269
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Y. Ohizumi
中科院分区：
文献类型：
--
作者：
M. Mitsui‐Saito;N. Nakahata;Y. Ohizumi
SK&F 96365 (1-[beta-[3-(4-methoxyphenyl)propoxyl]-4-methoxyphenethyl]-1H-imid azole hydrochloride) is widely used as an effective inhibitor of receptor-linked and capacitative Ca2+ entry. Since this inhibitor has additional effects such as inhibition of voltage-dependent Ca2+ channels, sarco- and endoplasmic reticula Ca2+ pumps and cell proliferation, its molecular mechanism of action remains to be solved. In the present study, we have investigated the effect of SK&F 96365 on microtubule protein isolated from bovine brain in vitro. SK&F 96365 depolymerized the polymerized microtubules in a concentration-dependent manner. This result suggests that SK&F 96365 directly depolymerizes microtubules, an effect that may contribute to the various actions of this compound.
影响因子：
9.7
作者：
Y. Lee;M. Sayeed;R. Wurster
通讯作者：
Y. Lee;M. Sayeed;R. Wurster
影响因子：
2.9
作者：
R. Toso;M. Jordan;K. Farrell;B. Matsumoto;L. Wilson
通讯作者：
R. Toso;M. Jordan;K. Farrell;B. Matsumoto;L. Wilson