MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
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DOI：
10.1016/j.brainres.2018.04.038
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发表时间：
2018-08-01
期刊：
影响因子：
2.9
通讯作者：
Watkins LR
中科院分区：
文献类型：
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作者：
Grace PM;Strand KA;Galer EL;Maier SF;Watkins LR
我们最近报道，从坐骨神经慢性缩窄性损伤(CCI)后10天开始的短疗程吗啡，在吗啡停药后延长了几个月的机械性异位痛觉持续时间。这种吗啡诱导的持续性敏化的维持依赖于小胶质细胞的反应性和Toll样受体4信号。鉴于miR-124和miR-146a等microRNAs(MiRNAs)具有调节这种信号的能力，我们直接比较了它们在该模型中的功能。我们发现，在我们的吗啡诱导的持续性敏化模型中，这两个miRNAs都逆转了已建立的异位痛觉。MiR-124和miR-146a的疗效相当，在两种情况下，异位痛觉在miRNA剂量结束后数小时内恢复到数天。我们的发现表明，针对Toll样受体信号的miRNAs在逆转神经病理性疼痛方面是有效的，这突显了这些非编码RNA的临床潜力。
We have recently reported that a short course of morphine, starting 10 days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization was dependent on microglial reactivity and Toll-like receptor 4 signaling. Given that microRNAs (miRNAs) such as miR-124 and miR-146a possess the ability to modulate such signaling, we directly compared their function in this model. We found that both miRNAs reversed established allodynia in our model of morphine-induced persistent sensitization. The efficacy of miR-124 and miR-146a were comparable, and in both cases allodynia returned within hours to days of miRNA dosing conclusion. Our findings demonstrate that miRNAs targeting Toll-like receptor signaling are effective in reversing neuropathic pain, which underscores the clinical potential of these non-coding RNAs.
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吗啡通过TLR4在大鼠脊髓损伤模型中通过TLR4扩增机械性异常。
影响因子：
15.1
作者：
Ellis, Amanda;Grace, Peter M.;Wieseler, Julie;Favret, Jacob;Springer, Kendra;Skarda, Bryce;Ayala, Monica;Hutchinson, Mark R.;Falci, Scott;Rice, Kenner C.;Maier, Steven F.;Watkins, Linda R.
通讯作者：
Watkins, Linda R.
DOI：
10.1016/j.bbi.2017.08.018
发表时间：
2018-08
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Grace PM;Strand KA;Galer EL;Rice KC;Maier SF;Watkins LR
通讯作者：
Watkins LR
影响因子：
5.3
作者：
Milligan, ED;O'Connor, KA;Watkins, LR
通讯作者：
Watkins, LR
影响因子：
13.5
作者：
Lacagnina MJ;Watkins LR;Grace PM
通讯作者：
Grace PM
影响因子：
82.9
作者：
通讯作者：
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