A role for host-parasite interactions in the horizontal transfer of transposons across phyla.
A role for host-parasite interactions in the horizontal transfer of transposons across phyla.
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作者：
水平转移（HT），或遗传物质在非交配物种之间的传递，越来越被认为是真核生物基因组进化的重要力量。转座子具有在基因组内调动和扩增的固有能力，可能特别容易发生HT。然而，转座子在广泛分化的物种中传播的方式仍然难以捉摸。在这里，我们提出的证据表明，宿主-寄生虫相互作用促进了无脊椎动物和脊椎动物之间四个转座子家族的HT。我们发现，长角Rhodnius prolixus是一种以各种四足动物的血液为食的三角蝽，也是人类恰加斯病的载体，它的基因组中携带着四个不同的转座子家族，这些转座子家族也侵入了一组不同但重叠的四足动物的基因组。臭虫的转座子与负鼠和松鼠猴的转座子在系统发育上有98%是相同的，它们是臭虫在南美洲最喜欢的两种哺乳动物宿主。我们还在池塘蜗牛中发现了一个转座子家族，这是一种几乎世界性的感染多种脊椎动物的吸虫载体，其祖先序列与旧大陆哺乳动物中的序列几乎相同并聚集在一起。总之，这些数据为先前假设的宿主-寄生虫相互作用在促进动物间HT中的作用提供了证据。此外，水平转移转座子扩增产生的大量DNA支持了宿主和寄生虫之间遗传物质交换影响其基因组进化的观点。
Horizontal transfer (HT), or the passage of genetic material between non-mating species, is increasingly recognized as an important force in the evolution of eukaryotic genomes. Transposons, with their inherent ability to mobilize and amplify within genomes, may be especially prone to HT. However, the means by which transposons can spread across widely diverged species remain elusive. Here we present evidence that host-parasite interactions have promoted the HT of four transposon families between invertebrates and vertebrates. We found that Rhodnius prolixus, a triatomine bug feeding on the blood of diverse tetrapods and vector of the Chagas disease in humans, carries in its genome four distinct transposon families that also invaded the genomes of a diverse, but overlapping, set of tetrapods. The bug transposons are ~98% identical and cluster phylogenetically with those of the opossum and squirrel monkey, two of its preferred mammalian hosts in South America. We also identified one of these transposon families in the pond snail Lymnaea stagnalis, a nearly cosmopolitan vector of trematodes infecting diverse vertebrates, whose ancestral sequence is nearly identical and clusters with those found in Old World mammals. Together these data provide evidence for a previously hypothesized role of host-parasite interactions in facilitating HT among animals. Furthermore, the large amount of DNA generated by the amplification of the horizontally-transferred transposons supports the idea that the exchange of genetic material between hosts and parasites influence their genomic evolution.
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DOI：
10.1093/bioinformatics/8.3.275
发表时间：
1992-06-01
期刊：
COMPUTER APPLICATIONS IN THE BIOSCIENCES
影响因子：
--
作者：
JONES, DT;TAYLOR, WR;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
1.7
作者：
Jurka, J;Kapitonov, VV;Walichiewicz, J
通讯作者：
Walichiewicz, J
影响因子：
56.9
作者：
Davis, CC;Wurdack, KJ
通讯作者：
Wurdack, KJ
影响因子：
9.2
作者：
Heath, BD;Butcher, RDJ;Hubbard, SF
通讯作者：
Hubbard, SF
影响因子：
5.3
作者：
FRIESEN, PD;NISSEN, MS
通讯作者：
NISSEN, MS