Transcription factor OTF-1 interacts with two distinct DNA elements in the A gamma-globin gene promoter.
Transcription factor OTF-1 interacts with two distinct DNA elements in the A gamma-globin gene promoter.
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转录因子 OTF-1 与 A γ-珠蛋白基因启动子中的两个不同 DNA 元件相互作用。
DOI：
10.1021/bi00225a033
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发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Lingrel,JB
中科院分区：
文献类型：
--
作者：
Ponce,E;Lloyd,JA;Pierani,A;Roeder,RG;Lingrel,JB
Revised Manuscript Received December 26, 1990 abstract: A DNA region (site II) in the promoter of the human A7-globin gene (-182 to-168) is involved in transcriptional regulation. At least two nuclear proteins bind to this region: the erythroid-specific factor NF-E1/GF-1 and another factor present in many cell lines. In thepresent study, we demonstrate that the ubiquitous factor binding to site II has immunological identity with the octamer transcription factor OTF-1, which has been implicated in the regulation of expression of genes such as histone H2b and small nuclear RNA. In addition, we show that OTF-1 binds to site I (-291 to-267), a purine-rich region upstream of site II. Interestingly, OTF-1 binds to sites I and II with equal affinity. This was unexpected since the 14 bp site I binding site Aag A AT AA ATT AG A (-291 to-278), determined by methylation interference, does not show obvious similarities to the canonical octamer binding site for OTF-1 in site II (ATGCAAAT). Interaction of OTF-1 with functionally active binding sites in the 7-globin promoter suggests that this factor has a role in 7-globin transcription.Developmental regulation of the human/3-globin gene locus involves a switch from fetal (7) to adult (/3) globin which initiates at approximately 32 weeks of gestation. Six months after birth, the switch is complete, and fetal hemoglobin (HbF), containing 7-globin chains, decreases andremains less than 1% of all the/3-like globins through adult life (Collins & Weissman, 1984). The mechanism by which this switch occurs is not understood. In the asymptomatic condition known as hereditary persistence of fetal hemoglobin (HPFH), the switch from 7-to (3-globin is incomplete, and significant levels of 7-globincontinue to be expressed during adult life
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免疫球蛋白 kappa 轻链基因的体外细胞类型特异性转录。
DOI：
10.1073/pnas.83.22.8511
发表时间：
1986
影响因子：
11.1
作者：
Mizushima-Sugano,J;Roeder,RG
通讯作者：
Roeder,RG
DOI：
10.1073/pnas.85.11.3840
发表时间：
1988-06
影响因子：
11.1
作者：
R. Costa;D. Grayson;K. Xanthopoulos;J. Darnell
通讯作者：
R. Costa;D. Grayson;K. Xanthopoulos;J. Darnell
免疫球蛋白κ轻链基因表达的两个调控元件。
DOI：
--
发表时间：
1984
影响因子：
11.1
作者：
Y. Bergman;D. Rice;R. Grosschedl;D. Baltimore
通讯作者：
D. Baltimore
影响因子：
64.8
作者：
DAVIDSON, I;FROMENTAL, C;CHAMBON, P
通讯作者：
CHAMBON, P
突变 HPFH γ-珠蛋白启动子的红细胞特异性表达增加需要红细胞因子 NFE-1
DOI：
--
发表时间：
1989
期刊：
影响因子：
--
作者：
S. Nicolis;A. Ronchi;Nicoletta Malgarctti;R. Mantovani;B. Giglioni;S. Ottolenghi
通讯作者：
S. Ottolenghi