Cellular Energetics of Mast Cell Development and Activation.
Cellular Energetics of Mast Cell Development and Activation.
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DOI：
10.3390/cells10030524
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发表时间：
2021-03-02
期刊：
影响因子：
6
通讯作者：
Brown JM
中科院分区：
文献类型：
--
作者：
Mendoza RP;Fudge DH;Brown JM
肥大细胞是先天免疫系统中必不可少的第一反应粒细胞，以其在 1 型免疫超敏反应中的作用而闻名。虽然肥大细胞因其在过敏中的作用而被广泛认可，但它对全身的其他系统有一系列影响，并且可以对多种激动剂做出反应，以正确启动适当的免疫反应。肥大细胞具有动态的能量代谢，可以快速响应其能量需求。然而，我们对肥大细胞代谢及其对肥大细胞活化和发育的影响的理解仍处于起步阶段。肥大细胞代谢在刺激和发育过程中在代谢的两个方面之间变化：分解代谢（例如糖酵解和氧化磷酸化）和合成代谢（例如磷酸戊糖途径）。代谢途径转变的潜力可能会优先于甚至控制激活和分化，这为探索能量代谢以寻找破译肥大细胞功能的线索提供了令人兴奋的机会。在这篇综述中，我们讨论了有关代谢环境和不同激活来源期间的波动的文献，特别是 IgE 介导的与非 IgE 介导的，以及肥大细胞发育，包括导致众所周知的常驻肥大细胞的祖细胞类型。
Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions. Although mostly recognized for their role in allergies, mast cells have a range of influences on other systems throughout the body and can respond to a wide range of agonists to properly prime an appropriate immune response. Mast cells have a dynamic energy metabolism to allow rapid responsiveness to their energetic demands. However, our understanding of mast cell metabolism and its impact on mast cell activation and development is still in its infancy. Mast cell metabolism during stimulation and development shifts between both arms of metabolism: catabolic metabolism—such as glycolysis and oxidative phosphorylation—and anabolic metabolism—such as the pentose phosphate pathway. The potential for metabolic pathway shifts to precede and perhaps even control activation and differentiation provides an exciting opportunity to explore energy metabolism for clues in deciphering mast cell function. In this review, we discuss literature pertaining to metabolic environments and fluctuations during different sources of activation, especially IgE mediated vs. non-IgE mediated, and mast cell development, including progenitor cell types leading to the well-known resident mast cell.
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影响因子：
14.2
作者：
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通讯作者：
Razin, Ehud
影响因子：
7.8
作者：
CHAKRAVARTY, N;ZEUTHEN, E
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通讯作者：
Manning BD
影响因子：
4.8
作者：
Feng, LX;Ravindranath, N;Dym, M
通讯作者：
Dym, M