Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap.
Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap.
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DOI：
10.1016/j.iac.2022.04.008
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发表时间：
2022-08
影响因子：
2.6
通讯作者：
Sharma, Sunita
中科院分区：
文献类型：
--
作者：
Hudler, Andi;Holguin, Fernando;Sharma, Sunita
虽然在ACO的发生中有许多潜在的机制在起作用，但我们尚未确定导致ACO患者临床表型的炎症和气道重塑的确切途径（表1）。有必要对这一亚组患者进行进一步研究，通过定义这种临床相关综合征的基础病理生理学，更好地阐明其病程的自然史。更好地了解导致ACO患者疾病严重程度增加的病理生理机制将有助于我们更好地确定潜在的药物靶点，改善ACO患者的症状负担和整体生活质量。
Although there are many potential mechanisms at play in the development of ACO, we have not yet identified the exact pathways of inflammation and airway remodeling that result in the clinical phenotypes we see in patients with ACO (Table 1). Further investigations with a dedicated focus on this subgroup of patients is warranted to better elucidate the natural history of their disease course by defining the underlying pathophysiology of this clinically relevant syndrome. A better understanding of the pathophysiologic mechanisms that result in increased disease severity in patients with ACO will help us to better identify potential drug targets and improve symptom burden and overall quality of life for patients living with ACO.
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DOI：
10.1056/nejmra0910061
发表时间：
2010-12-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fahy JV;Dickey BF
通讯作者：
Dickey BF
影响因子：
30.8
作者：
Demenais F;Margaritte-Jeannin P;Barnes KC;Cookson WOC;Altmüller J;Ang W;Barr RG;Beaty TH;Becker AB;Beilby J;Bisgaard H;Bjornsdottir US;Bleecker E;Bønnelykke K;Boomsma DI;Bouzigon E;Brightling CE;Brossard M;Brusselle GG;Burchard E;Burkart KM;Bush A;Chan-Yeung M;Chung KF;Couto Alves A;Curtin JA;Custovic A;Daley D;de Jongste JC;Del-Rio-Navarro BE;Donohue KM;Duijts L;Eng C;Eriksson JG;Farrall M;Fedorova Y;Feenstra B;Ferreira MA;Australian Asthma Genetics Consortium (AAGC) collaborators;Freidin MB;Gajdos Z;Gauderman J;Gehring U;Geller F;Genuneit J;Gharib SA;Gilliland F;Granell R;Graves PE;Gudbjartsson DF;Haahtela T;Heckbert SR;Heederik D;Heinrich J;Heliövaara M;Henderson J;Himes BE;Hirose H;Hirschhorn JN;Hofman A;Holt P;Hottenga J;Hudson TJ;Hui J;Imboden M;Ivanov V;Jaddoe VWV;James A;Janson C;Jarvelin MR;Jarvis D;Jones G;Jonsdottir I;Jousilahti P;Kabesch M;Kähönen M;Kantor DB;Karunas AS;Khusnutdinova E;Koppelman GH;Kozyrskyj AL;Kreiner E;Kubo M;Kumar R;Kumar A;Kuokkanen M;Lahousse L;Laitinen T;Laprise C;Lathrop M;Lau S;Lee YA;Lehtimäki T;Letort S;Levin AM;Li G;Liang L;Loehr LR;London SJ;Loth DW;Manichaikul A;Marenholz I;Martinez FJ;Matheson MC;Mathias RA;Matsumoto K;Mbarek H;McArdle WL;Melbye M;Melén E;Meyers D;Michel S;Mohamdi H;Musk AW;Myers RA;Nieuwenhuis MAE;Noguchi E;O'Connor GT;Ogorodova LM;Palmer CD;Palotie A;Park JE;Pennell CE;Pershagen G;Polonikov A;Postma DS;Probst-Hensch N;Puzyrev VP;Raby BA;Raitakari OT;Ramasamy A;Rich SS;Robertson CF;Romieu I;Salam MT;Salomaa V;Schlünssen V;Scott R;Selivanova PA;Sigsgaard T;Simpson A;Siroux V;Smith LJ;Solodilova M;Standl M;Stefansson K;Strachan DP;Stricker BH;Takahashi A;Thompson PJ;Thorleifsson G;Thorsteinsdottir U;Tiesler CMT;Torgerson DG;Tsunoda T;Uitterlinden AG;van der Valk RJP;Vaysse A;Vedantam S;von Berg A;von Mutius E;Vonk JM;Waage J;Wareham NJ;Weiss ST;White WB;Wickman M;Widén E;Willemsen G;Williams LK;Wouters IM;Yang JJ;Zhao JH;Moffatt MF;Ober C;Nicolae DL
通讯作者：
Nicolae DL
DOI：
10.1016/j.jaci.2018.04.013
发表时间：
2018-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Ghebre MA;Pang PH;Diver S;Desai D;Bafadhel M;Haldar K;Kebadze T;Cohen S;Newbold P;Rapley L;Woods J;Rugman P;Pavord ID;Johnston SL;Barer M;May RD;Brightling CE
通讯作者：
Brightling CE
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
5.9
作者：
Desai, Mauli;Oppenheimer, John;Tashkin, Donald P.
通讯作者：
Tashkin, Donald P.