Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
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IX 胶原蛋白基因多态性与腰椎间盘退变：系统评价和荟萃分析
DOI：
10.1186/s13018-018-0750-0
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发表时间：
2018-03-05
影响因子：
2.6
通讯作者：
Wei Q
中科院分区：
文献类型：
--
作者：
Wu H;Wang S;Chen W;Zhan X;Xiao Z;Jiang H;Wei Q
越来越多的研究探讨了IX型胶原α 2链（COL9A2）和IX型胶原α 3链（COL9A3）基因多态性与腰椎间盘退变（LDD）风险的关系。然而，这些研究得出了相互矛盾的结果。本荟萃分析的目的是探讨胶原IX基因多态性（COL9A2中的rs12077871，rs12722877，rs7533552; COL9A3中的rs61734651）与LDD之间的关联。最后一次电子检索于2017年9月1日进行。从每个研究中提取等位基因/基因型频率。使用比值比（OR）和95%置信区间（CI）评估5种比较遗传模型下的关联强度。结果共纳入病例对照研究10篇，其中LDD病例2102例，对照2507例，共纳入10篇病例对照研究。（rs12077871、rs12722877、rs7533552）和COL9A3基因（rs61734651）多态性与LDD无关rs12077871：T vs. C，OR = 1.85，95%CI = 0.87 - 3.91，P = 0.11; rs12722877：G vs. C，OR = 0.83，95%CI = 0.69 - 1.01，P = 0.06; rs7533552：rs61734651：T vs.C，OR = 1.57，95%CI = 0.51 - 4.84，P = 0.43）。结论COL9A2基因rs12077871、rs12722877、rs7533552变异和COL9A3基因rs61734651变异与LDD易感性无显著相关性。需要大规模和精心设计的研究来证实这一结论。
BackgroundAn increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD.MethodsAll relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI). The last electronic search was performed on September 1, 2017. The allele/genotype frequencies were extracted from each study. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of associations under the five comparison genetic models. Statistical analysis was performed by Review Manager (RevMan) 5.31 software.ResultsThe meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87–3.91,P= 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69–1.01,P= 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98–1.25,P= 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51–4.84,P= 0.43). The Egger text and the Begg funnel plot did not show any evidence of publication bias.Conclusionrs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. Large-scale and well-designed studies are needed to confirm this conclusion.
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DOI：
10.1016/j.bbrc.2014.03.025
发表时间：
2014-04-18
影响因子：
3.1
作者：
Seki, Shoji;Tsumaki, Noriyuki;Kimura, Tomoatsu
通讯作者：
Kimura, Tomoatsu
影响因子：
3
作者：
Furlan, Andrea D.;Pennick, Victoria;van Tulder, Maurits
通讯作者：
van Tulder, Maurits
椎间盘变性中的遗传因素。
影响因子：
6.8
作者：
Feng, Yi;Egan, Brian;Wang, Jinxi
通讯作者：
Wang, Jinxi
影响因子：
1
作者：
Rathod TN;Chandanwale AS;Gujrathi S;Patil V;Chavan SA;Shah MN
通讯作者：
Shah MN
影响因子：
2
作者：
Kalb, Samuel;Martirosyan, Nikolay L.;Theodore, Nicholas
通讯作者：
Theodore, Nicholas