Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
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DOI：
10.1016/j.ebiom.2017.03.020
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发表时间：
2017-07
期刊：
影响因子：
11.1
通讯作者：
von Zglinicki T
中科院分区：
文献类型：
--
作者：
Korolchuk VI;Miwa S;Carroll B;von Zglinicki T
细胞衰老越来越被认为是与衰老相关的健康和健身损失的主要贡献者。衰老细胞积累功能障碍的线粒体;氧化磷酸化效率降低，活性氧产生增加。在这篇综述中，我们将讨论如何营业额的线粒体（一个术语称为线粒体自噬）是在衰老的线粒体积累和衰老相关的线粒体功能障碍（SAMD）的扰动。我们将进一步探讨随后的细胞后果;特别是SAMD似乎是必要的，至少部分特定的衰老相关的分泌表型（SASP），并可能负责组织水平的代谢功能障碍，与衰老和肥胖。了解这些主要衰老相关表型之间的复杂相互作用将有助于选择和改善延长人类健康寿命的干预措施。本综述的数据通过检索MEDLINE、PubMed和相关文章的参考文献确定，检索词为“线粒体与衰老”、“（自噬或线粒体自噬）与衰老”、“线粒体自噬与衰老”和相关术语。此外，根据研究者姓名进行检索。会议的摘要和报告被排除在外。纳入了1995年至2017年期间以英语发表的文章。根据作者认为的与主题的相关性选择文章。线粒体自噬紊乱导致细胞衰老中的线粒体功能障碍。线粒体功能障碍驱动衰老细胞的多种特征表型。衰老相关的线粒体功能障碍可能是衰老代谢损害的重要原因。
Cell senescence is increasingly recognized as a major contributor to the loss of health and fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; oxidative phosphorylation efficiency is decreased and reactive oxygen species production is increased. In this review we will discuss how the turnover of mitochondria (a term referred to as mitophagy) is perturbed in senescence contributing to mitochondrial accumulation and Senescence-Associated Mitochondrial Dysfunction (SAMD). We will further explore the subsequent cellular consequences; in particular SAMD appears to be necessary for at least part of the specific Senescence-Associated Secretory Phenotype (SASP) and may be responsible for tissue-level metabolic dysfunction that is associated with aging and obesity. Understanding the complex interplay between these major senescence-associated phenotypes will help to select and improve interventions that prolong healthy life in humans. Data for this review were identified by searches of MEDLINE, PubMed, and references from relevant articles using the search terms “mitochondria AND senescence”, “(autophagy OR mitophagy) AND senescence”, “mitophagy AND aging” and related terms. Additionally, searches were performed based on investigator names. Abstracts and reports from meetings were excluded. Articles published in English between 1995 and 2017 were included. Articles were selected according to their relevance to the topic as perceived by the authors. Perturbed mitophagy contributes to mitochondrial dysfunction in cell senescence. Mitochondrial dysfunction drives multiple characteristic phenotypes of senescent cells. Senescence-associated mitochondrial dysfunction may be an important cause for metabolic compromise in aging.
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影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.15252/embj.201592862
发表时间：
2016-04-01
期刊：
The EMBO journal
影响因子：
--
作者：
Correia-Melo C;Marques FD;Anderson R;Hewitt G;Hewitt R;Cole J;Carroll BM;Miwa S;Birch J;Merz A;Rushton MD;Charles M;Jurk D;Tait SW;Czapiewski R;Greaves L;Nelson G;Bohlooly-Y M;Rodriguez-Cuenca S;Vidal-Puig A;Mann D;Saretzki G;Quarato G;Green DR;Adams PD;von Zglinicki T;Korolchuk VI;Passos JF
通讯作者：
Passos JF
DOI：
10.1016/j.bbamcr.2010.08.007
发表时间：
2011-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Deas E;Wood NW;Plun-Favreau H
通讯作者：
Plun-Favreau H
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
4.2
作者：
Cocco, Tiziana;Pacelli, Consiglia;Villani, Gaetano
通讯作者：
Villani, Gaetano