Cystic fibrosis-related diabetes: Prevalence, screening, and diagnosis.

Cystic fibrosis-related diabetes: Prevalence, screening, and diagnosis.
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DOI:
10.1016/j.jcte.2021.100290
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发表时间:
2022-03
影响因子:
3
通讯作者:
Chan CL
Chan CL
中科院分区:
其他
文献类型:
--
作者:
Khare S;Desimone M;Kasim N;Chan CL

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年度筛选OGTT根据ADA标准诊断。诊断特殊情况。囊性纤维化相关糖尿病(CFRD)是囊性纤维化(CF)患者最常见的合并症。CFRD的患病率随着年龄的增长而增加,并且随着严重突变而增加。其他与CFRD相关的危险因素包括女性、胰腺功能不全、肝脏疾病、需要胃造口管喂养、支气管肺曲霉病史和肺功能差。CFRD与更差的临床结局和更高的死亡率有关。早期诊断和治疗已被证明可以改善临床结果。建议从10岁开始每年进行口服葡萄糖耐量试验(OGTT)筛查CFRD。CFRD的诊断是由标准的美国糖尿病协会(ADA)标准在基线健康。CFRD也可以在急性疾病期间、肠内喂养期间和移植后诊断为CF患者。在这篇综述中,我们将讨论面板堆石坝的流行病学,并提供一个概述的优点和缺陷,目前的筛选和诊断试验面板堆石坝。
Annual screening. OGTT. Diagnosis by ADA criteria. Diagnosis special circumstances. Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). Prevalence of CFRD increases with age and is greater with severe mutations. Other risk factors associated with CFRD are female sex, pancreatic insufficiency, liver disease, need for gastrostomy tube feedings, history of bronchopulmonary aspergillosis, and poor pulmonary function. CFRD is related to worse clinical outcomes and increased mortality. Early diagnosis and treatment have been shown to improve clinical outcomes. Screening for CFRD is recommended with an annual oral glucose tolerance test (OGTT) starting at age 10 years. Diagnosis of CFRD is made by standard American Diabetes Association (ADA) criteria during baseline health. CFRD can also be diagnosed in individuals with CF during acute illness, while on enteral feeds, and after transplant. In this review we will discuss the epidemiology of CFRD and provide an overview of the advantages and pitfalls of current screening and diagnostic tests for CFRD.
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