Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.
Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.
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DOI：
10.1155/2012/672416
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发表时间：
2012
影响因子：
--
通讯作者：
Yagasaki K
中科院分区：
文献类型：
--
作者：
Kita Y;Miura Y;Yagasaki K
白藜芦醇是一种芪类化合物，是白藜芦醇的代谢产物，存在于红酒中。研究发现，白藜芦醇和口服白藜芦醇的大鼠血清可剂量依赖性地抑制培养中AH 109 A肝癌细胞的增殖和侵袭。低浓度（25~50 μM）时，其抗增殖作用是基于细胞周期阻滞，高浓度（100 μM）时，其抗增殖作用是基于诱导细胞凋亡。云杉烷醇通过清除细胞内活性氧抑制活性氧增强的侵袭能力。这些结果表明，与白藜芦醇不同，白藜芦醇具有通过诱导细胞周期停滞和诱导凋亡来抑制肝癌增殖的潜力。他们还表明，白藜芦醇的抗氧化特性，如白藜芦醇，可能涉及其抗侵袭作用。随后，发现云杉烷醇抑制肝癌荷瘤大鼠实体瘤的生长和转移。因此，Piceatannol可能是一种有用的抗癌天然产物。
Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM). Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species. These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction. They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action. Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats. Thus, piceatannol may be a useful anticancer natural product.
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DOI：
10.1016/s0006-291x(03)00725-3
发表时间：
2003-05-23
影响因子：
3.1
作者：
Miura, Y;Kozuki, Y;Yagasaki, K
通讯作者：
Yagasaki, K
影响因子：
9.7
作者：
Kozuki, Y;Miura, Y;Yagasaki, K
通讯作者：
Yagasaki, K
影响因子：
4
作者：
Miura, D;Miura, Y;Yagasaki, K
通讯作者：
Yagasaki, K
影响因子：
2.2
作者：
Zhang, GY;Miura, Y;Yagasaki, K
通讯作者：
Yagasaki, K
影响因子：
2.2
作者：
Miura, Y;Shiomi, H;Yagasaki, K
通讯作者：
Yagasaki, K