Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration.
Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration.
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DOI：
10.3390/pharmaceutics13020136
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发表时间：
2021-01-21
期刊：
影响因子：
5.4
通讯作者：
Yui N
中科院分区：
文献类型：
--
作者：
Terauchi M;Tamura A;Arisaka Y;Masuda H;Yoda T;Yui N
口腔组织再生因提高患者的生活质量而受到越来越多的关注。口腔组织如牙槽骨和广泛缺损骨的再生已经被广泛研究，包括使用治疗细胞和生长因子对口腔组织进行再生治疗。此外，促进骨形成的小分子药物已被确定并测试为新的再生治疗方法。然而，治疗需要进步，以实现口腔功能的成功再生。在这篇综述中，我们描述了口腔组织再生治疗的最新进展。我们特别关注环糊精（CD）为基础的药物和多电解质络合的生长因子，以提高其溶解度，稳定性和生物活性。CDs可以将疏水小分子药物封装到它们的空腔中，从而形成包合物。成骨诱导小分子药物的包合性提高了药物在水溶液中的溶解度，提高了体外成骨分化效率。此外，各种阴离子聚合物如肝素及其模拟聚合物已被开发，以提高生长因子的稳定性和生物活性。这些聚合物通过静电相互作用保护生长因子免于失活和降解，从而增强骨形成能力。这些使用包合物和多电解质复合物的方法在口腔组织再生中具有很大的潜力。
Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. Additionally, small-molecule drugs that promote bone formation have been identified and tested as new regenerative treatment. However, treatments need to progress to realize successful regeneration of oral functions. In this review, we describe recent progress in development of regenerative treatment of oral tissues. In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. CDs can encapsulate hydrophobic small-molecule drugs into their cavities, resulting in inclusion complexes. The inclusion complexation of osteoinductive small-molecule drugs improves solubility of the drugs in aqueous solutions and increases in vitro osteogenic differentiation efficiency. Additionally, various anionic polymers such as heparin and its mimetic polymers have been developed to improve stability and bioactivity of growth factors. These polymers protect growth factors from deactivation and degradation by complex formation through electrostatic interaction, leading to potentiation of bone formation ability. These approaches using an inclusion complex and polyelectrolyte complexes have great potential in the regeneration of oral tissues.
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影响因子：
6
作者：
Babu RJ;Dayal P;Singh M
通讯作者：
Singh M
影响因子：
1.9
作者：
Boyne, PJ;Lilly, LC;Triplett, RG
通讯作者：
Triplett, RG
DOI：
10.1073/pnas.70.9.2702
发表时间：
1973-01-01
影响因子：
11.1
作者：
ARMELIN, HA
通讯作者：
ARMELIN, HA
影响因子：
4.3
作者：
BOWERS, GM;CHADROFF, B;ROMBERG, E
通讯作者：
ROMBERG, E
影响因子：
10.8
作者：
Eguchi, M;Ooya, T;Yui, N
通讯作者：
Yui, N