Realization of the reversible vesicle-micelle transition of vitamin-derived bolaamphiphiles by heat change monitoring.
Realization of the reversible vesicle-micelle transition of vitamin-derived bolaamphiphiles by heat change monitoring.
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通过热变化监测实现维生素衍生的双亲物的可逆囊泡-胶束转变。
DOI：
10.1021/jp3071184
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zhongxiu Chen
中科院分区：
文献类型：
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作者：
Yu;Si Wang;Xue Han;Zhongxiu Chen
采用等温滴定量热法（ITC）研究了由十六烷基三甲基溴化铵（CTAB）、十二烷基硫酸钠（SDS）和Triton X-100 （TX100）等表面活性剂诱导的两性离子型维生素源型亲水分子（DDO）囊泡结构变化的实时能量学。CTAB和SDS与DDO的相互作用都伴随着大量的热释放，而TX-100与囊泡的相互作用能量很小。然而，在添加所有三种表面活性剂时，DDO囊泡确实发生了向胶束的转变。在热流焓图上观察到细小的拐点，系统地反映了囊泡结构的变化。通过监测CTAB与DDO的相互作用，我们发现在较高温度下，在一定浓度范围内放热保持恒定。揭示了加热的修复作用，实现了DDO从胶束到囊泡的可逆转变。荧光素在DDO囊泡中的进一步包封证明了可逆的囊泡-胶束转变是可控的。本研究表明，ITC与动态光散射（DLS）和透射电子显微镜（TEM）等互补分析方法相结合，有助于获得囊泡结构变化的实时信息。这些合成的新型亲水分子为设计可控释放系统提供了广阔的前景。
The real-time energetics involved in the structural change of a zwitterionic vitamin-derived bolaamphiphiles (DDO) vesicles, which were induced by conventional surfactants, such as hexadecyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS), and Triton X-100 (TX100), was characterized by isothermal titration calorimetry (ITC). Interactions of both CTAB and SDS with DDO were accompanied with considerable heat release whereas the interaction energetics between TX-100 and the vesicles were small. However, the transition of DDO vesicles to micelles did occur upon the addition of all of the three surfactants. Fine inflection points were observed in heat flow enthalpograms, which indicated systematically the change of vesicle structure. By monitoring the interaction of CTAB with DDO, we found that heat release kept constant over a certain concentration range at higher temperatures. The repairing effect of heating was revealed and a reversible transition from micelles to vesicles of DDO was thus realized. Further encapsulation of fluorescein in DDO vesicles proved that the reversible vesicle-micelle transition was controllable. This research demonstrates that ITC combined with complementary analytical methods such as dynamic light scattering (DLS) and transmission electron microscopy (TEM) helps to get the real-time information of the structural changes of vesicles. It also shows that these synthetic novel bolaamphiphiles offer great promise for designing controllable release system.
DOI：
10.1021/la052125t
发表时间：
2006-01
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Xue-Long Sun;Nilanjan Biswas;T. Kai;Z. Dai;R. Dluhy;E. Chaikof
通讯作者：
Xue-Long Sun;Nilanjan Biswas;T. Kai;Z. Dai;R. Dluhy;E. Chaikof