Studies of Mast Cells: Adventures in Serendipity.
Studies of Mast Cells: Adventures in Serendipity.
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DOI：
10.3389/fimmu.2018.00520
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发表时间：
2018
影响因子：
7.3
通讯作者：
Brown MA
中科院分区：
文献类型：
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作者：
Brown MA
就像我们许多有幸与比尔·保罗共事的人一样，我的科学生涯也因与他的交往而发生了不可估量的变化。虽然一开始他在免疫学界的地位令人生畏，但很快就清楚了，他不仅真正关心我们一起做的具体研究，而且他希望向他的学员传达一种开放的、不断质疑的、无限有趣的科学方法。他的热情很有感染力，在接受他的培训后，尽管有资金和出版障碍带来的压力，但我从未后悔自己选择的道路。我的研究发生了一个急转弯，从我计划在与比尔合作后继续研究适应性免疫，到一生都在探索肥大细胞的奇妙之处，肥大细胞是一种相对罕见的先天免疫细胞。这是因为比尔的好奇心和对意外的期待，让他回想起来，看到了我们一起做的一个相当平凡的观察，涉及一个非生理转化的肥大细胞系，这可能真的很有趣。我从来没有忘记这一课：用大局的眼光看数据。有时候，意想不到的结果比预期的结果更有趣。他在这方面的例子是非常重要的，因为作为一个独立的研究者，在老鼠性别决定上的一个错误导致了意想不到的和非常混乱的数据。然而，这些数据最终揭示了肥大细胞在实验性自身免疫性脑脊髓炎（多发性硬化症小鼠模型）中具有男性特异性保护作用。比尔在免疫学方面的影响是深远的，我们这些培养自己的学生和博士后的人将继续感受到他的智慧和科学研究方法。
Like many of us who had the great fortune to work with Bill Paul, my science life was immeasurably altered by my interactions with him. Although intimidating at first because of his stature in the immunology world, it was soon clear that he not only truly cared about the specific research we were doing together, but he wished to convey to his trainees an approach to science that was open, always questioning, and infinitely fun. His enthusiasm was infectious and after my training with him, despite stresses due to funding and publishing hurdles, I never regretted the path I took. My research took a sharp turn from the studies of adaptive immunity I had planned on pursuing after my fellowship with Bill to a life long quest to understand the wonders of the mast cell, a relatively rare innate immune cell. This came about because Bill’s curiosity and expectation of the unexpected allowed him to view, in retrospect, a rather mundane observation we made together involving a non-physiological transformed mast cell line as something that might be really interesting. I have never forgotten that lesson: Look at the data with an eye on the big picture. Sometimes the unexpected is more interesting than predicted results. His example in this regard was incredibly important when as an independent investigator a mistake in mouse sex determination led to unexpected and very confusing data. Yet, these data ultimately revealed a role for mast cells in male-specific protection in experimental autoimmune encephalomyelitis, the mouse model of multiple sclerosis. Bill’s influence in immunology is far-reaching and will continue to be felt as those of us who train our own students and post-doctoral fellows pass on his wisdom and approach to scientific research.
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影响因子：
7.2
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
32.4
作者：
Croxford, Andrew L.;Lanzinger, Margit;Becher, Burkhard
通讯作者：
Becher, Burkhard
影响因子：
10.5
作者：
Coussens, LM;Raymond, WW;Hanahan, D
通讯作者：
Hanahan, D
影响因子：
32.4
作者：
Gri G;Piconese S;Frossi B;Manfroi V;Merluzzi S;Tripodo C;Viola A;Odom S;Rivera J;Colombo MP;Pucillo CE
通讯作者：
Pucillo CE
影响因子：
30.5
作者：
通讯作者：
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