Neuronal selectivity to complex vocalization features emerges in the superficial layers of primary auditory cortex.
Neuronal selectivity to complex vocalization features emerges in the superficial layers of primary auditory cortex.
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神经元对复杂发声特征的选择性出现在初级听觉皮层的表层。
DOI：
10.1371/journal.pbio.3001299
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发表时间：
2021-06
期刊：
影响因子：
9.8
通讯作者：
Sadagopan S
中科院分区：
文献类型：
--
作者：
Montes-Lourido P;Kar M;David SV;Sadagopan S
在听觉处理的早期，神经反应忠实地反映声音输入。然而，在听觉处理的更高阶段，神经元对特定的呼叫类型变得有选择性，最终导致皮层的专门区域优先处理最高听觉处理阶段的呼叫。我们以前提出，在如何将非选择性反应转化为呼叫选择性反应的中间步骤是信息呼叫功能的检测。但是，如何信息呼叫功能的神经选择性出现从非选择性输入，功能选择性是否逐渐出现在处理层次，以及刺激信息是如何表示在非选择性和功能选择性人口仍然是一个悬而未决的问题。在这项研究中，使用未麻醉的豚鼠（GPs），一个高度发声和社会的啮齿动物，作为动物模型，我们的特点是在3个听觉加工阶段的神经代表的呼叫丘脑（腹内侧膝状体（vMGB）），丘脑感受器（L4）和浅层（L2/3）的初级听觉皮层（A1）。我们发现，vMGB和A1 L4的神经元没有表现出呼叫选择性反应，并在整个呼叫持续时间作出反应。然而，A1 L2/3神经元表现出高的呼叫选择性，约三分之一的神经元仅对1或2种呼叫类型作出反应。这些A1 L2/3神经元只响应有限的部分调用，这表明他们是高度选择性的呼叫功能。这些A1 L2/3神经元的感受野表现出复杂的spectrotemporal结构，这可能是其高呼叫功能选择性的基础。信息论分析表明，在A1 L4，刺激信息分布在人口和传播的呼叫持续时间。与此相反，在A1 L2/3，个别神经元表现出短暂的高刺激特异性信息的爆发，并传达高水平的信息每穗。这些数据表明，在A1 L4和A1 L2/3之间发生的电话的神经表征的转换，导致出现的一个基于特征的代表性的电话在A1 L2/3。因此，我们的数据表明，所观察到的皮质专门呼叫处理出现在A1和设置阶段，进一步的机制研究。在豚鼠中引起的同种呼叫在不同的听觉处理阶段的神经元表征的研究揭示了洞察呼叫选择性神经元反应出现的地方，从非选择性呼叫选择性反应的转换发生在初级听觉皮层的浅层。
Early in auditory processing, neural responses faithfully reflect acoustic input. At higher stages of auditory processing, however, neurons become selective for particular call types, eventually leading to specialized regions of cortex that preferentially process calls at the highest auditory processing stages. We previously proposed that an intermediate step in how nonselective responses are transformed into call-selective responses is the detection of informative call features. But how neural selectivity for informative call features emerges from nonselective inputs, whether feature selectivity gradually emerges over the processing hierarchy, and how stimulus information is represented in nonselective and feature-selective populations remain open question. In this study, using unanesthetized guinea pigs (GPs), a highly vocal and social rodent, as an animal model, we characterized the neural representation of calls in 3 auditory processing stages—the thalamus (ventral medial geniculate body (vMGB)), and thalamorecipient (L4) and superficial layers (L2/3) of primary auditory cortex (A1). We found that neurons in vMGB and A1 L4 did not exhibit call-selective responses and responded throughout the call durations. However, A1 L2/3 neurons showed high call selectivity with about a third of neurons responding to only 1 or 2 call types. These A1 L2/3 neurons only responded to restricted portions of calls suggesting that they were highly selective for call features. Receptive fields of these A1 L2/3 neurons showed complex spectrotemporal structures that could underlie their high call feature selectivity. Information theoretic analysis revealed that in A1 L4, stimulus information was distributed over the population and was spread out over the call durations. In contrast, in A1 L2/3, individual neurons showed brief bursts of high stimulus-specific information and conveyed high levels of information per spike. These data demonstrate that a transformation in the neural representation of calls occurs between A1 L4 and A1 L2/3, leading to the emergence of a feature-based representation of calls in A1 L2/3. Our data thus suggest that observed cortical specializations for call processing emerge in A1 and set the stage for further mechanistic studies. A study of the neuronal representations elicited in guinea pigs by conspecific calls at different auditory processing stages reveals insights into where call-selective neuronal responses emerge; the transformation from nonselective to call-selective responses occurs in the superficial layers of the primary auditory cortex.
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影响因子：
64.5
作者：
Egger R;Tupikov Y;Elmaleh M;Katlowitz KA;Benezra SE;Picardo MA;Moll F;Kornfeld J;Jin DZ;Long MA
通讯作者：
Long MA
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
22.4
作者：
CLIFF, N
通讯作者：
CLIFF, N
影响因子：
1.7
作者：
GLASS, I;WOLLBERG, Z
通讯作者：
WOLLBERG, Z
影响因子：
2.5
作者：
Bauer, EE;Klug, A;Pollak, GD
通讯作者：
Pollak, GD