Immunomodulatory Medication Use in Newly Diagnosed Youth With Systemic Lupus Erythematosus.
Immunomodulatory Medication Use in Newly Diagnosed Youth With Systemic Lupus Erythematosus.
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DOI：
10.1002/acr.24392
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发表时间：
2021-11
影响因子：
4.7
通讯作者：
Knight, Andrea
中科院分区：
文献类型：
--
作者：
Davis, Alaina;Chang, Joyce;Shapiro, Sarah;Klein-Gitelman, Marisa;Faerber, Jennifer;Katcoff, Hannah;Cidav, Zuleyha;Mandell, David S.;Knight, Andrea
研究系统性红斑狼疮（SLE）青年患者在第一年护理期间糖皮质激素保留免疫调节药物的使用情况。我们使用Clinformatics DataMart提供的2000年至2013年的行政索赔进行了一项回顾性队列研究，研究对象为10-24岁的年轻人，偶发性诊断为SLE（≥3个国际疾病分类第九版SLE代码[710.0]，每个代码间隔>30天）。我们确定了在首次SLE代码（索引日期）的12个月内填写免疫调节药物处方的受试者比例。我们使用多变量回归来检查人口统计学/疾病因素与第一年处方填写时间之间的关联，以及索引日期后任何时间的处方填写之间的关联。我们确定了532名患有SLE的年轻人，其中413名（78%）在第一年服用了糖皮质激素保留免疫调节剂。羟氯喹和免疫抑制剂的处方在第一年分别由366名青年（69%）和182名青年（34%）填写。成人发病（与儿童发病）疾病的患者在12个月内不太可能服用免疫调节药物。未发现其他统计学显著相关性，尽管随后每个日历年免疫调节药物填充的可能性增加。在新诊断的SLE患者中，羟氯喹的使用虽然不普遍，但很普遍，在治疗的第一年，处方免疫抑制剂的使用明显较低。需要进一步的研究来确定在第一年护理期间导致免疫调节药物使用不佳的因素。
To examine glucocorticoid-sparing immunomodulatory medication use in youth with systemic lupus erythematosus (SLE) during their first year of care. We conducted a retrospective cohort study using administrative claims for 2000 to 2013 from Clinformatics DataMart for youth ages 10–24 years with an incident diagnosis of SLE (≥3 International Classification of Diseases, Ninth Revision codes for SLE [710.0], each >30 days apart). We determined the proportion of subjects filling a prescription for immunomodulatory medications within 12 months of the first SLE code (index date). We used multivariable regression to examine associations between demographic/disease factors and time to prescription fill in the first year, and also between prescription fill at any time after the index date. We identified 532 youth with an incident SLE diagnosis, of which 413 (78%) had a glucocorticoid-sparing immunomodulatory prescription fill in the first year. Prescriptions for hydroxychloroquine and immunosuppressants were filled in the first year by 366 youth (69%) and by 182 (34%), respectively. Those with adult-onset (versus childhood-onset) disease were less likely to fill an immunomodulatory medication by 12 months. No other statistically significant associations were found, although there was increasing likelihood of immunomodulatory medication fills with each subsequent calendar year. Among youth with newly diagnosed SLE, hydroxychloroquine use is prevalent although not universal, and prescription immunosuppressant use is notably low during the first year of care. Further research is needed to identify factors contributing to suboptimal immunomodulatory medication use during the first year of care.
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影响因子：
27.4
作者：
Bertsias GK;Tektonidou M;Amoura Z;Aringer M;Bajema I;Berden JH;Boletis J;Cervera R;Dörner T;Doria A;Ferrario F;Floege J;Houssiau FA;Ioannidis JP;Isenberg DA;Kallenberg CG;Lightstone L;Marks SD;Martini A;Moroni G;Neumann I;Praga M;Schneider M;Starra A;Tesar V;Vasconcelos C;van Vollenhoven RF;Zakharova H;Haubitz M;Gordon C;Jayne D;Boumpas DT;European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
通讯作者：
European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
影响因子：
2.6
作者：
Hanly, J. G.;Thompson, K.;Skedgel, C.
通讯作者：
Skedgel, C.
影响因子：
--
作者：
Brunner, Hermine I.;Gladman, Dafna D.;Silverman, Earl D.
通讯作者：
Silverman, Earl D.
影响因子：
4.7
作者：
Hersh, Aimee O.;Trupin, Laura;Yelin, Edward
通讯作者：
Yelin, Edward
影响因子：
--
作者：
Bernatsky, S.;Boivin, J. -F.;Ramsey-Goldman, R.
通讯作者：
Ramsey-Goldman, R.