Determining the Roles that Club Drugs, Marijuana, and Heavy Drinking Play in PrEP Medication Adherence Among Gay and Bisexual Men: Implications for Treatment and Research.
Determining the Roles that Club Drugs, Marijuana, and Heavy Drinking Play in PrEP Medication Adherence Among Gay and Bisexual Men: Implications for Treatment and Research.
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DOI：
10.1007/s10461-018-2309-9
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发表时间：
2019-05
影响因子：
4.4
通讯作者：
Parsons JT
中科院分区：
文献类型：
--
作者：
Grov C;Rendina HJ;John SA;Parsons JT
研究人员已经确定，物质使用会干扰感染艾滋病毒的男同性恋和双性恋男性 (GBM) 的抗逆转录病毒药物依从性。 HIV 阴性 GBM 中暴露前预防 (PrEP) 依从性的平行检查有限。我们对 104 名使用 PrEP 的 GBM 进行了为期 10 周的回顾性 30 天时间线随访访谈和前瞻性半周日记数据，其中一半参与俱乐部毒品使用（氯胺酮、摇头丸、GHB、可卡因或甲基苯丙胺），生成 9,532 天的数据。参与者报告了他们每天的 PrEP、俱乐部毒品、大麻和大量饮酒（一次喝 5 杯以上）的情况。平均而言，俱乐部吸毒者比非俱乐部吸毒者错过一剂 PrEP 的可能性并不高（M = 1.6 剂，SD = 3.0，过去 30 天）。然而，我们发现俱乐部吸毒（在活动层面）使当天漏服药物的几率增加了 55%，第二天漏服药物的几率（例如，“残留效应”）增加了 60%。此外，如果有一天漏服一剂，第二天漏服一剂的几率会增加八倍。我们没有发现吸食大麻或大量饮酒对 PrEP 依从性的事件水平影响。我们的数据表明，与时间驱动的 PrEP 方案相比，俱乐部吸毒者可以通过每日口服或长效注射 PrEP 获得更大的保护作用，因为俱乐部吸毒者和 PrEP 不依从性同时存在。
Researchers have established that substance use interferes with anti-retroviral medication adherence among gay and bisexual men (GBM) living with HIV. There is limited parallel examination of pre-exposure prophylaxis (PrEP) adherence among HIV-negative GBM. We conducted retrospective 30-day timeline follow-back interviews and prospective semi-weekly diary data for 10 weeks with 104 PrEP-using GBM, half of whom engaged in club drug use (ketamine, ecstasy, GHB, cocaine, or methamphetamine)—generating 9,532 days of data. Participants reported their day-by-day PrEP, club drug, marijuana, and heavy alcohol use (5+ drinks in one sitting). On average, club drug users were no more likely to miss a dose of PrEP than non-club drug users (M = 1.6 doses, SD = 3.0, past 30 days). However, we found that club drug use (at the event level) increased the odds of missing a dose on the same day by 55% and the next day (e.g., a “carryover effect”) by 60%. Further, missing a dose on one day increased the odds of missing a dose the following day by eight-fold. We did not identify an event-level effect of marijuana use or heavy drinking on PrEP adherence. Our data suggest club drug users could have greater protective effects from daily oral or long-acting injectable PrEP compared to a time-driven PrEP regimen because of the concurrence of club drug use and PrEP non-adherence.
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影响因子：
4.4
作者：
Greene GJ;Swann G;Fought AJ;Carballo-Diéguez A;Hope TJ;Kiser PF;Mustanski B;D'Aquila RT
通讯作者：
D'Aquila RT
影响因子：
4.4
作者：
Feinstein BA;Newcomb ME
通讯作者：
Newcomb ME
影响因子：
4.4
作者：
Boone, Melissa R.;Cook, Stephanie H.;Wilson, Patrick
通讯作者：
Wilson, Patrick
影响因子：
1.8
作者：
Grov, Christian;Parsons, Jeffrey T.;Bimbi, David S.
通讯作者：
Bimbi, David S.
DOI：
10.1097/qad.0b013e328336e98b
发表时间：
2010-04-24
期刊：
AIDS (London, England)
影响因子：
--
作者：
Das M;Santos D;Matheson T;Santos GM;Chu P;Vittinghoff E;Shoptaw S;Colfax GN
通讯作者：
Colfax GN