MicroRNAs and inflammation in the pathogenesis and progression of colon cancer.
MicroRNAs and inflammation in the pathogenesis and progression of colon cancer.
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DOI：
10.1159/000341882
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Harris CC
中科院分区：
文献类型：
--
作者：
Okayama H;Schetter AJ;Harris CC
炎症、改变的microRNA（miRNA）表达和结肠癌之间存在密切联系。长期的炎症性肠病相关结肠炎导致结直肠癌（CRC）发展的风险增加，而散发性CRC部分由炎症微环境驱动，这支持炎症在结肠癌发生中的致病作用。miRNAs是一类小的非编码RNA，最近成为炎症和癌症的关键参与者。一些miRNA作为炎症介质，其他的可以作为癌基因或肿瘤抑制因子，这取决于它们表达的细胞环境。特别是，miR-21是一种致癌的miRNA，它被认为是一种炎症介质，并可能促进炎症相关的结肠癌发生。miRNAs具有作为CRC生物标志物和治疗靶点的潜力。它们目前正在被评估为早期检测生物标志物和预后分类器。miRNA和miRNA结合位点的多态性可能会改变CRC的风险。本文就炎症和miRNAs在结直肠癌发生中的作用进行综述，并探讨miRNAs和炎症基因作为结直肠癌生物标志物和治疗靶点的潜力。
There is a strong connection between inflammation, altered microRNA (miRNA) expression and colon cancer. Longstanding inflammatory bowel diseases-related colitis leads to increased risk for the development of colorectal cancer (CRC), while sporadic CRC is in part driven by the inflammatory microenvironment This supports a causative role for inflammation in colon carcinogenesis. miRNAs are a class of small noncoding RNAs that have recently emerged as key players in both inflammation and cancer. Some miRNAs act as inflammatory mediators, others can act as either oncogenes or tumor suppressors depending on the cellular environment in which they are expressed. In particular, miR-21 is an oncogenic miRNA that has been implicated as an inflammatory mediator and may promote inflammation-associated colon carcinogenesis. miRNAs have potential as biomarkers and therapeutic targets in CRC. They are currently being evaluated as early detection biomarkers and prognostic classifiers. Polymorphisms in miRNAs and miRNA-binding sites may alter one’s risk of CRC. This review will focus on the role of inflammation and miRNAs in colon carcinogenesis and discuss the potential for miRNAs and Inflammatory genes to be used as biomarkers and therapeutic targets of CRC.
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影响因子：
8.8
作者：
Diosdado B;van de Wiel MA;Terhaar Sive Droste JS;Mongera S;Postma C;Meijerink WJ;Carvalho B;Meijer GA
通讯作者：
Meijer GA
影响因子：
3.7
作者：
Cheng H;Zhang L;Cogdell DE;Zheng H;Schetter AJ;Nykter M;Harris CC;Chen K;Hamilton SR;Zhang W
通讯作者：
Zhang W
DOI：
10.1093/jnci/91.1.86
发表时间：
1999-01-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Ambs, S;Bennett, WP;Harris, CC
通讯作者：
Harris, CC
影响因子：
56.9
作者：
Kim, SF;Huri, DA;Snyder, SH
通讯作者：
Snyder, SH
影响因子：
5.2
作者：
Akcakaya, Pinar;Ekelund, Susanne;Lui, Weng-Onn
通讯作者：
Lui, Weng-Onn