Enhancement of Pancreatic Secretion by Dietary Protein in Rats with Chronic Diversion of Bile‐Pancreatic Juice from the Proximal Small Intestine
Enhancement of Pancreatic Secretion by Dietary Protein in Rats with Chronic Diversion of Bile‐Pancreatic Juice from the Proximal Small Intestine
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膳食蛋白质增强近端小肠胆汁胰液慢性转移的大鼠胰腺分泌
DOI：
10.1097/00006676-199403000-00021
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发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
S. Kiriyama
中科院分区：
文献类型：
--
作者：
H. Hara;H. Narakino;S. Kiriyama
已知的是，饮食蛋白对胰酶分泌的调节依赖于大鼠近端小肠管腔内的胰蛋白酶活性，这是一种负反馈机制。我们观察了在不受限制和不麻醉的条件下，饮食蛋白质是否刺激大鼠的胰腺分泌，其中大鼠的胆胰液(BPJ)在自由和非麻醉条件下从近端小肠分流7天。在慢性BPJ改道的大鼠，观察到禁食状态下的蛋白水解酶的高分泌，饲喂25%酪蛋白饲料后的胰酶分泌明显高于禁食状态下的高分泌。改道大鼠摄食后分泌物增加的幅度与正常大鼠相当。饮食脂肪减少了蛋白质饮食刺激的分泌，但对正常大鼠没有影响。我们的结论是，胰酶分泌对饮食蛋白的反应存在上小肠BPJ非依赖的机制，饮食脂肪抑制了改道大鼠的胰腺分泌。远端的小肠或结肠可能参与了这种抑制。
The regulation of exocrine pancreatic enzyme secretion by dietary protein is known to depend on pancreatic protease activity in the lumen of the proximal small intestine in rats, which is a negative feedback mechanism. We observed whether dietary protein stimulates pancreatic secretion in rats with a 7-day diversion of bile-pancreatic juice (BPJ) from the proximal small intestine under unrestrained and unanesthetized conditions. In the chronically BPJ-diverted rats, hypersecretion of proteases in the fasting state were observed, and pancreatic enzyme secretion was significantly increased after feeding of a 25% casein diet over the hypersecretion in the fasting state. The amplitude of the increments of the secretion after feeding in diverted rats was comparable to that in normal rats. Dietary fat decreased stimulated secretion by the protein diet in the diverted rats, but not in the normal rats. We conclude that there is an upper small intestinal BPJ-independent mechanism for response of pancreatic enzyme secretion to dietary protein, and that dietary fat inhibits pancreatic secretion in diverted rats. The distal small intestine or colon may contribute to the inhibition.
肽YY和胰多肽对大鼠外分泌胰腺的抑制性调节。
DOI：
10.1152/ajpgi.1989.256.4.g698
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Putnam,WS;Liddle,RA;Williams,JA
通讯作者：
Williams,JA
胆囊收缩素释放肽介导胰腺分泌的反馈调节。
DOI：
10.1152/ajpgi.1989.256.2.g430
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Lu,L;Louie,D;Owyang,C
通讯作者：
Owyang,C
胆囊收缩素减少介导胆汁盐诱导的胰腺生长的抑制。
DOI：
10.1152/ajpgi.1990.259.1.g86
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Gomez,G;TownsendJr,CM;Green,DW;Rajaraman,S;GreeleyJr,GH;Thompson,JC
通讯作者：
Thompson,JC