Brain perivascular macrophages: characterization and functional roles in health and disease.
Brain perivascular macrophages: characterization and functional roles in health and disease.
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DOI：
10.1007/s00109-017-1573-x
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Iadecola C
中科院分区：
文献类型：
--
作者：
Faraco G;Park L;Anrather J;Iadecola C
血管周围巨噬细胞（PVM）是一个独特的群体的居民脑巨噬细胞的特点是密切相关的脑血管。PVM在发育早期从卵黄囊迁移到大脑中，并且像小胶质细胞一样，可能是一种自我更新的细胞群，在正常状态下，不被循环单核细胞补充。越来越多的证据表明PVM与多种疾病过程有关，从脑感染和免疫激活到高血压、阿尔茨海默病病理或肥胖背景下下下丘脑-肾上腺轴和神经血管-神经认知功能障碍的调节。这些影响涉及PVM和脑内皮细胞之间的串扰，与循环免疫细胞的相互作用，和/或活性氧的产生。总的来说，现有的证据支持PVM是脑驻留免疫系统的关键组成部分，对主要脑疾病的发病机制具有广泛的影响。更好地了解PVM的生物学和病理生物学可能会为各种脑部疾病带来新的见解和治疗策略。
Perivascular macrophages (PVM) are a distinct population of resident brain macrophages characterized by a close association with the cerebral vasculature. PVM migrate from the yolk sac into the brain early in development and, like microglia, are likely to be a self-renewing cell population that, in the normal state, is not replenished by circulating monocytes. Increasing evidence implicates PVM in several disease processes, ranging from brain infections and immune activation to regulation of the hypothalamic-adrenal axis and neurovascular-neurocognitive dysfunction in the setting of hypertension, Alzheimer disease pathology, or obesity. These effects involve crosstalk between PVM and cerebral endothelial cells, interaction with circulating immune cells, and/or production of reactive oxygen species. Overall, the available evidence supports the idea that PVM are a key component of the brain-resident immune system with broad implications for the pathogenesis of major brain diseases. A better understanding of the biology and pathobiology of PVM may lead to new insights and therapeutic strategies for a wide variety of brain diseases.
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影响因子：
30.5
作者：
Goldmann T;Wieghofer P;Jordão MJ;Prutek F;Hagemeyer N;Frenzel K;Amann L;Staszewski O;Kierdorf K;Krueger M;Locatelli G;Hochgerner H;Zeiser R;Epelman S;Geissmann F;Priller J;Rossi FM;Bechmann I;Kerschensteiner M;Linnarsson S;Jung S;Prinz M
通讯作者：
Prinz M
影响因子：
32.4
作者：
Herz J;Filiano AJ;Wiltbank AT;Yogev N;Kipnis J
通讯作者：
Kipnis J
DOI：
10.1152/ajpheart.00679.2010
发表时间：
2011-01-01
影响因子：
4.8
作者：
Capone, Carmen;Faraco, Giuseppe;Iadecola, Costantino
通讯作者：
Iadecola, Costantino
影响因子：
25
作者：
Kierdorf, Katrin;Erny, Daniel;Prinz, Marco
通讯作者：
Prinz, Marco
影响因子：
5.3
作者：
Bechmann, I;Kwidzinski, E;Nitsch, R
通讯作者：
Nitsch, R