The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study.
The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study.
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DOI：
10.1016/j.metop.2023.100261
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发表时间：
2023-12
期刊：
影响因子：
--
通讯作者：
Kenneth J. Mukamal
中科院分区：
文献类型：
--
作者：
Yakubu Bene-Alhasan;David S. Siscovick;Joachim H. Ix;Jorge R. Kizer;Russell Tracy;Luc Djousse;Kenneth J. Mukamal
非酯化脂肪酸（NEFA）是预防衰老的关键心脏代谢疾病的潜在靶点，但其人群水平相关性仍不确定。我们试图确定与老年人空腹和负荷后NEFA水平相关的可改变因素。我们使用线性回归来确定参加心血管健康研究的社区居住老年人（n = 1924）的人口统计学、人体测量学和生活方式特征以及药物使用与血清空腹和负荷后NEFA浓度的横断面相关性。空腹NEFA水平通常表现出更广泛的一组决定因素，而负荷后NEFA更一致地与代谢因素相关。腰围和体重与较高的空腹和负荷后NEFA相关。吸烟和咖啡因摄入量与两种动物的较低水平相关，适度饮酒与较高的空腹水平相关，而更多的消费与较低的负荷后水平相关。与较高的空腹NEFA相关的独特因素包括女性性别、较高的年龄、袢和噻嗪类利尿剂的使用和钙的摄入，而与较低的空腹水平相关的因素包括较高的教育程度、β受体阻滞剂的使用和蛋白质的摄入。白天睡眠时间与较高的负荷后NEFA相关，而DASH评分与较低的水平相关。空腹和负荷后NEFA有共同和独特的可改变的风险因素，包括社会人口统计学，人体测量，药物和饮食。负荷后NEFA对代谢因素特别敏感，而更广泛的决定因素与空腹水平相关。这些因素值得研究作为降低老年人NEFA水平的目标。
Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load NEFA levels in older adults. We used linear regression to determine the cross-sectional associations of demographic, anthropometric, and lifestyle characteristics and medication use with serum fasting and post-load NEFA concentrations amongst community-dwelling older adults enrolled in the Cardiovascular Health Study (n = 1924). Fasting NEFA levels generally demonstrated a broader set of determinants, while post-load NEFA were more consistently associated with metabolic factors. Waist circumference and weight were associated with higher fasting and post-load NEFA. Cigarette smoking and caffeine intake were associated with lower levels of both species, and moderate alcohol intake was associated with higher fasting levels whereas greater consumption was associated with lower post-load levels. Unique factors associated with higher fasting NEFA included female sex, higher age, loop and thiazide diuretic use and calcium intake, while factors associated with lower fasting levels included higher educational attainment, beta-blocker use, and protein intake. Hours spent sleeping during the daytime were associated with higher post-load NEFA, while DASH score was associated with lower levels. Fasting and post-load NEFA have both common and unique modifiable risk factors, including sociodemographics, anthropometric, medications, and diet. Post-load NEFA were particularly sensitive to metabolic factors, while a broader range of determinants were associated with fasting levels. These factors warrant study as targets for lowering levels of NEFA in older adults.
影响因子：
16.2
作者：
Djoussé L;Khawaja O;Bartz TM;Biggs ML;Ix JH;Zieman SJ;Kizer JR;Tracy RP;Siscovick DS;Mukamal KJ
通讯作者：
Mukamal KJ