Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults.
Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults.
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DOI：
10.2337/dc11-1690
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发表时间：
2012-08
期刊：
影响因子：
16.2
通讯作者：
Mukamal KJ
中科院分区：
文献类型：
--
作者：
Djoussé L;Khawaja O;Bartz TM;Biggs ML;Ix JH;Zieman SJ;Kizer JR;Tracy RP;Siscovick DS;Mukamal KJ
研究脂肪酸结合蛋白（FABP）4和非酯化脂肪酸（NEFA）与老年人糖尿病的关系。我们根据降糖药物的使用、空腹血糖≥126 mg/dL或非空腹血糖≥200 mg/dL，确定了3，740名心血管健康研究参与者（1992-2007）中的糖尿病事件。FABP 4和NEFA是在1992年和1993年之间收集的标本上测量的。3,740名受试者的平均年龄为74.8岁。对于log FABP 4的每一个SD增加，糖尿病的风险比（HR）在女性中为1.35（95% CI 1.10-1.65），在男性中为1.45（1.13-1.85），控制了年龄、种族、教育、体力活动、胱抑素C、酒精摄入、吸烟、自我报告的健康状况和女性雌激素使用（性别-FABP 4相互作用P 0.10）。BMI改变了FABP 4-糖尿病的关系（总体P = 0.009;女性为0.02，男性为0.135），因为糖尿病的统计学显著性较高风险主要见于BMI <25 kg/m2的男性（HR/SD：1.78 [95% CI 1.13-2.81]）。NEFA与糖尿病之间存在中度和非显著性关联（P趋势= 0.21）。然而，当仅限于前5年随访时，糖尿病的多变量校正HR为1.0（参考文献），1.68（95% CI 1.12-2.53）和1.63（1.07-2.50）（P趋势= 0.03）。血浆FABP 4与老年人的糖尿病发病率呈正相关，这种相关性仅在瘦人中具有统计学意义。在前5年的随访中，观察到血浆NEFA与糖尿病事件之间存在显著的正相关。
To examine the relation of fatty acid–binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992–2007) based on the use of hypoglycemic medications, fasting glucose ≥126 mg/dL, or nonfasting glucose ≥200 mg/dL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993. Mean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10–1.65) for women and 1.45 (1.13–1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m2 (HR per SD: 1.78 [95% CI 1.13–2.81]). There was a modest and nonsignificant association of NEFA with diabetes (Ptrend = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68 (95% CI 1.12–2.53), and 1.63 (1.07–2.50) across consecutive tertiles of NEFA (Ptrend = 0.03). Plasma FABP4 was positively associated with incident diabetes in older adults, and such association was statistically significant in lean men only. A significant positive association between plasma NEFA and incident diabetes was observed during the first 5 years of follow-up.
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影响因子：
11.1
作者：
Roden, M.;Mariz, S.;Pacini, G.
通讯作者：
Pacini, G.
影响因子：
7.2
作者：
PSATY, BM;LEE, M;LYLES, M
通讯作者：
LYLES, M
影响因子：
3.3
作者：
Hsu, Bang-Gee;Chen, Yu-Chih;Wang, Ji-Hung
通讯作者：
Wang, Ji-Hung
DOI：
10.1111/j.1365-2362.2006.01696.x
发表时间：
2006-09-01
影响因子：
5.5
作者：
Stejskal, D.;Karpisek, M.
通讯作者：
Karpisek, M.
影响因子：
16.2
作者：
Fu AZ;Qiu Y;Radican L;Wells BJ
通讯作者：
Wells BJ