Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration.
Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration.
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基于三维生物打印干细胞的心血管再生组织工程研究进展。
DOI：
10.1016/j.yjmcc.2022.04.017
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发表时间：
2022-08
影响因子：
5
通讯作者：
Huang, Ngan F.
中科院分区：
文献类型：
--
作者：
Khanna, Astha;Ayan, Bugra;Undieh, Ada A.;Yang, Yunzhi P.;Huang, Ngan F.
细胞或生物组分的三维（3D）生物打印是开发模拟心血管组织的空间、机械化学和时间特征的组织结构的新兴领域。3D多细胞和多结构域器官型生物构建体可以更好地概括体内生理学，并且可以用于各种应用。这些应用包括体外细胞研究、高通量药物筛选、疾病建模、生物相容性分析、药物测试和再生医学。3D生物打印策略的一个主要挑战是基质分子无法重建细胞外基质的复杂性以及内在的细胞形态和功能。一个重要的因素是包含血管网络，以促进可扩展和图案化的3D生物打印组织中的氧气和营养灌注，从而促进细胞活力和功能。在这篇综述中，我们总结了新一代的3D生物打印技术，用于3D生物打印的生物墨水和打印材料的种类，沿着当前最先进的工程化心血管组织模型。我们还强调了3D生物打印在心肌、心脏瓣膜和血管移植物工程中的转化应用。最后，我们讨论了当前的挑战和前景，设计有效的3D生物打印结构与天然血管，架构和功能的临床翻译和心血管再生。
Three-dimensional (3D) bioprinting of cellular or biological components are an emerging field to develop tissue structures that mimic the spatial, mechanochemical and temporal characteristics of cardiovascular tissues. 3D multi-cellular and multi-domain organotypic biological constructs can better recapitulate in vivo physiology and can be utilized in a variety of applications. Such applications include in vitro cellular studies, high-throughput drug screening, disease modeling, biocompatibility analysis, drug testing and regenerative medicine. A major challenge of 3D bioprinting strategies is the inability of matrix molecules to reconstitute the complexity of the extracellular matrix and the intrinsic cellular morphologies and functions. An important factor is the inclusion of a vascular network to facilitate oxygen and nutrient perfusion in scalable and patterned 3D bioprinted tissues to promote cell viability and functionality. In this review, we summarize the new generation of 3D bioprinting techniques, the kinds of bioinks and printing materials employed for 3D bioprinting, along with the current state-of-the-art in engineered cardiovascular tissue models. We also highlight the translational applications of 3D bioprinting in engineering the myocardium cardiac valves, and vascular grafts. Finally, we discuss current challenges and perspectives of designing effective 3D bioprinted constructs with native vasculature, architecture and functionality for clinical translation and cardiovascular regeneration.
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4D 打印：最新进展回顾。
影响因子：
3.4
作者：
Chu H;Yang W;Sun L;Cai S;Yang R;Liang W;Yu H;Liu L
通讯作者：
Liu L
用于工程心脏组织的生物打印技术的最新进展。
DOI：
10.1016/j.msec.2021.112057
发表时间：
2021-05
影响因子：
7.9
作者：
Agarwal, Tarun;Fortunato, Gabriele Maria;Hann, Sung Yun;Ayan, Bugra;Vajanthri, Kiran Yellappa;Presutti, Dario;Cui, Haitao;Chan, Alex H. P.;Costantini, Marco;Onesto, Valentina;Di Natale, Concetta;Huang, Ngan F.;Makvandi, Pooyan;Shabani, Majid;Maiti, Tapas Kumar;Zhang, Lijie Grace;De Maria, Carmelo
通讯作者：
De Maria, Carmelo
影响因子：
13.6
作者：
Cui, Haitao;Liu, Chengyu;Zhang, Lijie Grace
通讯作者：
Zhang, Lijie Grace
影响因子：
9
作者：
Campos, Daniela F. Duarte;Blaeser, Andreas;Fischer, Horst
通讯作者：
Fischer, Horst
影响因子：
8.4
作者：
An, Jia;Chua, Chee Kai;Mironov, Vladimir
通讯作者：
Mironov, Vladimir