Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis.
Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis.
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血清硒水平与妊娠期糖尿病：系统评价和荟萃分析
DOI：
10.1186/s12937-016-0211-8
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发表时间：
2016-10-28
影响因子：
5.4
通讯作者：
Zhou JQ
中科院分区：
文献类型：
--
作者：
Kong FJ;Ma LL;Chen SP;Li G;Zhou JQ
背景血清硒水平与妊娠期糖尿病（GDM）之间的关系存在争议。我们研究的目的是系统回顾现有的硒与 GDM 相关的文献，以全面了解人类血清硒水平与 GDM 之间的关系。方法检索 PubMed、The Cochrane Library 和 Medline 中截至 2016 年 8 月发表的研究。手动检索相关原始研究的参考文献。使用固定或随机效应模型测量汇总估计值。总体效果以标准平均差（SMD）报告。所有数据均使用 Review Manager 5.3 和 Stata 12.0 进行分析。结果 在审查的 44 篇参考文献中，涉及 569 名患者的 7 项研究符合我们的纳入标准并有助于荟萃分析。所有研究均用于评估血清硒水平与GDM之间的关系。患有 GDM 的女性的硒水平显着低于非 GDM 的女性 (SMD = -1.17; 95% CI: -1.98 至 -0.35,P= 0.005)。亚组分析显示，这种趋势在非白人人群中是一致的（亚洲：SMD = -2.82；95% CI：-5.21至-0.43，P= 0.02；非洲：SMD = -0.56；95% CI：-1.07至-0.05，P= 0.03）和妊娠晚期（SMD = -1.78；95% CI：-3.04 至 -0.52，P= 0.006），但不在高加索人群中（欧洲：SMD = -0.6；95% CI：-1.98 至 0.78，P= 0.39）或在妊娠中期（SMD = -0.68；95% CI：-1.98 至 0.78，P= 0.39）。 95% CI：-1.6 至 0.25，P= 0.15）。结论现有证据表明，GDM 女性的血清硒水平低于糖耐量正常的女性，特别是在非白人人群和妊娠晚期。然而，需要精心设计的前瞻性研究来了解硒状况与 GDM 风险之间的动态关联。
BackgroundThe association between serum selenium level and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking selenium to GDM for a comprehensive understanding of the relationship between serum selenium level and GDM in human.MethodsPubMed, The Cochrane Library and Medline were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were carried out. Pooled estimates were measured using the fixed or random effect model. Overall effect was reported in a standard mean difference (SMD). All data were analyzed with Review Manager 5.3 and Stata 12.0.ResultsOf 44 references reviewed, seven studies involving 569 patients met our inclusion criteria and contributed to meta-analysis. All the studies were used to evaluate the relationship between serum selenium level and GDM. Selenium level was significantly lower in women with GDM than those without GDM (SMD = −1.17; 95 % CI: −1.98 to −0.35,P= 0.005). Subgroup analysis showed that such trend was consistent within the non-Caucasian population (Asia: SMD = −2.82; 95 % CI: −5.21 to −0.43,P= 0.02; Africa: SMD = −0.56; 95 % CI: −1.07 to −0.05,P= 0.03) and in the third trimester (SMD = −1.78; 95 % CI: −3.04 to −0.52,P= 0.006), but not within the Caucasian population (Europe: SMD = −0.6; 95 % CI: −1.98 to 0.78,P= 0.39) or in the second trimester (SMD = −0.68; 95 % CI: −1.6 to 0.25,P= 0.15).ConclusionsThe available evidences suggested that serum selenium level was lower in women with GDM than those with normal glucose tolerance, especially within the non-Caucasian population and in the third trimester. However, well-designed prospective studies are needed to understand dynamic associations between selenium status and GDM risk.
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影响因子：
1.3
作者：
Hamdan, H. Z.;Elbashir, L. M.;Adam, I.
通讯作者：
Adam, I.
DOI：
10.1111/dme.12381
发表时间：
2014-03
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Catalano PM
通讯作者：
Catalano PM
DOI：
10.3109/14767058.2011.587921
发表时间：
2012-06-01
影响因子：
1.8
作者：
Jiwani, Aliya;Marseille, Elliot;Kahn, James G.
通讯作者：
Kahn, James G.
影响因子：
4.4
作者：
Bo, S;Lezo, A;Pagano, GF
通讯作者：
Pagano, GF
影响因子：
3.9
作者：
Kilinc, Metin;Guven, Melih A.;Coskun, Ayhan
通讯作者：
Coskun, Ayhan