Virulence reduction in bacteriophage resistant bacteria.
Virulence reduction in bacteriophage resistant bacteria.
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DOI：
10.3389/fmicb.2015.00343
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发表时间：
2015
影响因子：
5.2
通讯作者：
Bastías R
中科院分区：
文献类型：
--
作者：
León M;Bastías R
噬菌体可以影响细菌群落的丰度、多样性和进化。据报道，几种噬菌体可以向宿主添加毒力因子并增加细菌毒力。然而，裂解性噬菌体也可以施加选择压力，允许毒力降低的菌株增殖。这种减少可以解释为噬菌体利用细菌表面的结构作为受体，这可能是不同细菌物种的毒力因子。因此，这些受体发生修饰的菌株将对噬菌体感染具有抵抗力，并且还可能表现出毒力降低。这篇小型评论总结了有关毒力降低的噬菌体抗性菌株的报告，并讨论了噬菌体治疗和使用噬菌体选择疫苗减毒菌株的潜在后果。
Bacteriophages can influence the abundance, diversity, and evolution of bacterial communities. Several bacteriophages have been reported to add virulence factors to their host and to increase bacterial virulence. However, lytic bacteriophages can also exert a selective pressure allowing the proliferation of strains with reduced virulence. This reduction can be explained because bacteriophages use structures present on the bacterial surface as receptors, which can be virulence factors in different bacterial species. Therefore, strains with modifications in these receptors will be resistant to bacteriophage infection and may also exhibit reduced virulence. This mini-review summarizes the reports on bacteriophage-resistant strains with reductions in virulence, and it discusses the potential consequences in phage therapy and in the use of bacteriophages to select attenuated strains for vaccines.
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影响因子：
3.2
作者：
HEIERSON, A;SIDEN, I;BOMAN, HG
通讯作者：
BOMAN, HG
影响因子：
4.4
作者：
Choi, Younho;Shin, Hakdong;Ryu, Sangryeol
通讯作者：
Ryu, Sangryeol
影响因子：
4
作者：
Kao, D. -Y.;Cheng, Y. -C.;Chen, W. -J.
通讯作者：
Chen, W. -J.
影响因子：
3.1
作者：
Feldman, M;Bryan, R;Prince, A
通讯作者：
Prince, A
影响因子：
6.4
作者：
Collins, LV;Kristian, SA;Peschel, A
通讯作者：
Peschel, A