Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice
Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice
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植物乳杆菌 CCFM639 缓解慢性铝暴露小鼠肝脏和肾脏中微量元素失衡相关的氧化应激
DOI：
10.1007/s12011-016-0843-8
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发表时间：
2017-04
影响因子：
3.9
通讯作者：
Wei Chen
中科院分区：
文献类型：
--
作者：
Leilei Yu;Qixiao Zhai;Ruijie Yin;Peng Li;Fengwei Tian;Xiaoming Liu;Jianxin Zhao;Jianhua Gong;Hao Zhang;Wei Chen
铝（Al）对人类和动物的健康有各种不利影响。本研究旨在证明植物乳杆菌CCFM639可以减轻慢性铝暴露对小鼠肝脏和肾脏的不良影响。将动物分配到对照组、仅CCFM 639组、仅Al组、Al加CCFM 639组和Al加去铁酮组。通过口服管饲法给予菌株14周，并且在前8周通过饮用水引入Al。进行了粪便、血液和组织中铝和微量元素水平的分析。测定肝脏和肾脏中氧化应激的生化标志物（GSH、GPx、SOD、CAT和MDA）以及血液中ALT、AST、BUN和CRE的水平。结果表明，L.植物CCFM639能显著降低组织中铝的积累，调节微量元素的失衡，从而减轻肝、肾组织的氧化应激和病理变化。因此，L.植物CCFM639可减轻铝对肝、肾的损伤，其机制可能与调节微量元素失衡有关。
Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCFM639, and Al plus deferiprone groups. The strain was given by oral gavage for 14 weeks, and Al was introduced via drinking water for the first 8 weeks. Analyses of Al and trace elements levels in feces, blood, and tissues were performed. The biochemical markers (GSH, GPx, SOD, CAT, and MDA) of oxidative stress in livers and kidneys, as well as the levels of ALT, AST, BUN, and CRE in blood, were determined. Our results showed that L. plantarum CCFM639 can significantly reduce Al accumulation in tissues, regulate imbalance of trace elements, and thereby alleviate oxidative stress and pathological changes in hepatic and renal tissues. Therefore, L. plantarum CCFM639 could alleviate Al-induced hepatic and renal injuries, and the possible mechanisms may involve in regulating the imbalance of trace elements.
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影响因子：
3.9
作者：
Yang Yang-Yang;Hong Wang;Yuanxin Guo;Wenjuan Lei;Jianfeng Wang;Xinyue Hu;Junqing Yang;Qin He
通讯作者：
Yang Yang-Yang;Hong Wang;Yuanxin Guo;Wenjuan Lei;Jianfeng Wang;Xinyue Hu;Junqing Yang;Qin He
DOI：
10.1152/ajpgi.00024.2012
发表时间：
2012-07-01
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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