Prediction of antidepressant treatment response from gray matter volume across diagnostic categories
Prediction of antidepressant treatment response from gray matter volume across diagnostic categories
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根据跨诊断类别的灰质体积预测抗抑郁治疗反应
DOI：
10.1016/j.euroneuro.2013.07.004
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发表时间：
2013
影响因子：
5.6
通讯作者：
M. Czisch
中科院分区：
文献类型：
--
作者：
P. Sämann;D. Höhn;N. Chechko;S. Kloiber;S. Lucae;M. Ising;F. Holsboer;M. Czisch
功能障碍的边缘系统，边缘系统和前额叶脑回路代表了药物治疗所针对的重性抑郁症的神经基质。在一项高分辨率结构磁共振成像（MRI）研究中，我们研究了皮质体积变异性预测抑郁症患者抗抑郁治疗反应的潜力。我们招募了167名参与慕尼黑抗抑郁反应特征（MARS）研究的患者，并采用基于体素的形态测量法研究5周内灰质（GM）图与抑郁严重程度变化的协变。较大的左海马和双侧后扣带回GM体积和较低的右颞外侧GM体积与有益的治疗反应相关。胼胝体下/眶额GM体积与治疗反应相关，主要是通过性别与区域的相互作用。海马/颞外侧复合标记物在首次发作和复发的单极患者和双相患者中被证明是稳健的。与92名健康对照者相比，仅在左侧海马区检测到异常低的体积，特别是在复发性单极患者中。这些发现表明，特定脑区皮质体积的变化与抗抑郁药的不同反应有关。此外，海马的发现递归地将复发性抑郁症的不利治疗反应和进行性海马结构变化联系在一起。
Dysfunctional limbic, paralimbic and prefrontal brain circuits represent neural substrates of major depression that are targeted by pharmacotherapy. In a high resolution structural magnetic resonance imaging (MRI) study we investigated the potential of variability of the cortex volume to predict the response to antidepressant treatment among patients with major depression. We enrolled 167 patients participating in the Munich Antidepressant Response Signature (MARS) study and employed voxel based morphometry to investigate covariation of gray matter (GM) maps with changes of depression severity over 5 weeks. Larger left hippocampal and bilateral posterior cingulate GM volumes and lower right temporolateral GM volumes were associated with beneficial treatment response. Subcallosal/orbitofrontal GM volumes were associated with treatment response mainly through gender-by-region interactions. A hippocampal/temporolateral composite marker proved robust in both first episode and recurrent unipolar patients and in bipolar patients. Compared with 92 healthy controls, abnormally low volumes were only detected in the left hippocampal area, particularly in recurrent unipolar patients. These findings indicate that variability of the cortex volume of specific brain areas is associated with different response to antidepressants. In addition, hippocampal findings recursively link together unfavorable treatment response and progressive hippocampal structural changes in recurrent depression.
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影响因子：
17.7
作者：
Vythilingam, M;Heim, C;Bremner, JD
通讯作者：
Bremner, JD
影响因子：
17.7
作者：
Pizzagalli, D;Pascual-Marqui, RD;Davidson, RJ
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影响因子：
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Moore, Gregory J.;Cortese, Bernadette M.;Manji, Husseini K.
通讯作者：
Manji, Husseini K.
影响因子：
17.7
作者：
Ballmaier, M;Toga, AW;Kumar, A
通讯作者：
Kumar, A