Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
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KORA、TwinsUK 和 LLS 食品消费全表观基因组关联研究的汇总分析。
DOI：
10.1007/s00394-022-03074-9
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发表时间：
2023-04
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
检查表观遗传模式是识别疾病病理生理学分子变化的关键步骤，其中 DNA 甲基化是最容易获得的表观遗传测量。建议饮食通过表观遗传修饰影响新陈代谢和健康。因此，我们的目的是探索食物消耗与 DNA 甲基化之间的关联。在三个队列中进行了全表观基因组关联研究：KORA FF4、TwinsUK 和莱顿长寿研究，并对 37 种饮食暴露进行了评估。三个队列的食物组定义是一致的。 DNA 甲基化使用 KORA 中的 Infinium MmethylationEPIC BeadChip 和 Leiden 研究和 TwinsUK 研究中的 Infinium HumanMmethylation450 BeadChip 进行测量。总体而言，纳入了 2293 名中年男性和女性的数据。固定效应荟萃分析汇总了特定研究的估计值。每个食品组的错误发现率调整 p 值的显着性阈值设置为 0.05。我们发现 CpG 位点的甲基化水平与洋葱和大蒜 (2)、坚果和种子 (18)、牛奶 (1)、奶油 (11)、植物油 (4)、黄油 (13) 和酒精饮料 (27) 的摄入量之间存在显着关联。这些信号针对与代谢健康相关的基因，例如 GLI1、RPTOR 和 DIO1 等。该 EWAS 的独特之处在于它重点关注西方饮食中的食物类别。重要的发现主要与高脂肪含量的食物组有关。在线版本包含可在 10.1007/s00394-022-03074-9 获取的补充材料。
Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation. Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated. Food group definition was harmonized across the three cohorts. DNA methylation was measured using Infinium MethylationEPIC BeadChip in KORA and Infinium HumanMethylation450 BeadChip in the Leiden study and the TwinsUK study. Overall, data from 2293 middle-aged men and women were included. A fixed-effects meta-analysis pooled study-specific estimates. The significance threshold was set at 0.05 for false-discovery rate-adjusted p values per food group. We identified significant associations between the methylation level of CpG sites and the consumption of onions and garlic (2), nuts and seeds (18), milk (1), cream (11), plant oils (4), butter (13), and alcoholic beverages (27). The signals targeted genes of metabolic health relevance, for example, GLI1, RPTOR, and DIO1, among others. This EWAS is unique with its focus on food groups that are part of a Western diet. Significant findings were mostly related to food groups with a high-fat content. The online version contains supplementary material available at 10.1007/s00394-022-03074-9.
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影响因子：
4.7
作者：
Gart E;van Duyvenvoorde W;Toet K;Caspers MPM;Verschuren L;Nielsen MJ;Leeming DJ;Souto Lima E;Menke A;Hanemaaijer R;Keijer J;Salic K;Kleemann R;Morrison MC
通讯作者：
Morrison MC
DOI：
10.1016/j.bbrc.2018.10.040
发表时间：
2018-11-10
影响因子：
3.1
作者：
Onufer EJ;Tay S;Barron LK;Courtney CM;Warner BW;Guo J
通讯作者：
Guo J
影响因子：
3.7
作者：
Kowall, Bernd;Rathmann, Wolfgang;Meisinger, Christa
通讯作者：
Meisinger, Christa
影响因子：
3.2
作者：
Illner, Anne-Kathrin;Harttig, Ulrich;Boeing, Heiner
通讯作者：
Boeing, Heiner
影响因子：
5.2
作者：
Balduzzi, Sara;Ruecker, Gerta;Schwarzer, Guido
通讯作者：
Schwarzer, Guido