Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.
Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.
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DOI：
10.1016/j.ymgme.2014.11.010
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发表时间：
2015-01
影响因子：
3.8
通讯作者：
Mootha, Vamsi K.
中科院分区：
文献类型：
--
作者：
Lennerz, Belinda S.;Vafai, Scott B.;Delaney, Nigel F.;Clish, Clary B.;Deik, Amy A.;Pierce, Kerry A.;Ludwig, David S.;Mootha, Vamsi K.
苯甲酸钠是一种广泛使用的防腐剂，存在于许多食品和软饮料中。它在线粒体内代谢产生马尿酸，然后由肾脏清除。我们以前曾报道，摄入苯甲酸钠在一般认为是安全的（GRAS）剂量导致一个强大的波动，血浆马尿酸水平。由于先前的报告表明苯甲酸盐和马尿酸盐对细胞和动物模型中葡萄糖稳态的不良影响，我们假设苯甲酸盐可能代表人类中广泛且未被充分认识的致糖尿病饮食暴露。在此，我们通过对14名超重受试者进行随机、对照、交叉研究，评估急性暴露于GRAS水平的苯甲酸钠是否会改变胰岛素和葡萄糖稳态。在存在或不存在苯甲酸钠的情况下，在口服葡萄糖激发后收集系列血液样品。结果测量包括葡萄糖、胰岛素、胰高血糖素以及基于时间质谱的代谢谱。我们没有发现急性口服苯甲酸钠对葡萄糖稳态的统计学显著影响。在目标的146种代谢物中，有4种对苯甲酸盐的反应发生了显著变化，包括苯甲酸盐和马尿酸盐的预期升高。此外，邻氨基苯甲酸，色氨酸代谢产物，表现出强劲的上升，而乙酰甘氨酸下降。虽然我们的研究表明，GRAS剂量的苯甲酸盐不会对葡萄糖稳态产生急性不良影响，但未来的研究将有必要探索慢性苯甲酸盐暴露对代谢的影响。
Sodium benzoate is a widely used preservative found in many foods and soft drinks. It is metabolized within mitochondria to produce hippurate, which is then cleared by the kidneys. We previously reported that ingestion of sodium benzoate at the generally regarded as safe (GRAS) dose leads to a robust excursion in the plasma hippurate level. Since previous reports demonstrated adverse effects of benzoate and hippurate on glucose homeostasis in cells and in animal models, we hypothesized that benzoate might represent a widespread and underappreciated diabetogenic dietary exposure in humans. Here, we evaluated whether acute exposure to GRAS levels of sodium benzoate alters insulin and glucose homeostasis through a randomized, controlled, cross-over study of 14 overweight subjects. Serial blood samples were collected following an oral glucose challenge, in the presence or absence of sodium benzoate. Outcome measurements included glucose, insulin, glucagon, as well as temporal mass spectrometry-based metabolic profiles. We did not find a statistically significant effect of an acute oral exposure to sodium benzoate on glucose homeostasis. Of the 146 metabolites targeted, four changed significantly in response to benzoate, including the expected rise in benzoate and hippurate. In addition, anthranilic acid, a tryptophan metabolite, exhibited a robust rise, while acetylglycine dropped. Although our study shows that GRAS doses of benzoate do not have an acute, adverse effect on glucose homeostasis, future studies will be necessary to explore the metabolic impact of chronic benzoate exposure.
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影响因子：
9.9
作者：
Shaham, Oded;Wei, Ru;Wang, Thomas J.;Ricciardi, Catherine;Lewis, Gregory D.;Vasan, Ramachandran S.;Carr, Steven A.;Thadhani, Ravi;Gerszten, Robert E.;Mootha, Vamsi K.
通讯作者：
Mootha, Vamsi K.
影响因子：
15.9
作者：
DEVRIES, A;ALEXANDER, B
通讯作者：
ALEXANDER, B
影响因子：
5
作者：
MINEO, H;OHDATE, T;YANAIHARA, N
通讯作者：
YANAIHARA, N
影响因子：
158.5
作者：
BATSHAW, ML;BRUSILOW, S;SCHAFER, IA
通讯作者：
SCHAFER, IA
影响因子：
7.7
作者：
Ho JE;Larson MG;Vasan RS;Ghorbani A;Cheng S;Rhee EP;Florez JC;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ